Prymnesin-B1 Explained

Prymnesin-B1 is a chemical with the molecular formula . It is a member of the prymnesins, a class of ladder-frame polyether phycotoxins made by the alga Prymnesium parvum. It is known to be toxic to fish. It is a so called "B-type" prymnesin, which differ in the number of backbone cycles when compared to A-type prymnesins like prymnesin-2.^[1]

Structures

Prymnesins-B1 is formed of a large polyether polycyclic core with several conjugate double and triple bonds, chlorine and nitrogen heteroatoms and a single sugar moiety consisting of α-D-galactopyranose.

Biosynthesis

The backbone of B-type prymnesins like prymnesin-B1 is reportedly made by giant polyketide synthase enzymes dubbed the "PKZILLAs".^{[2] [3]}

See also

• Prymnesin-1
• Prymnesin-2

Notes and References

1. Rasmussen . Silas Anselm . Meier . Sebastian . Andersen . Nikolaj Gedsted . Blossom . Hannah Eva . Duus . Jens Øllgaard . Nielsen . Kristian Fog . Hansen . Per Juel . Larsen . Thomas Ostenfeld . Chemodiversity of Ladder-Frame Prymnesin Polyethers in Prymnesium parvum . Journal of Natural Products . American Chemical Society (ACS) . 79 . 9 . 2016-08-23 . 0163-3864 . 10.1021/acs.jnatprod.6b00345 . 2250–2256. 27550620 . free .
2. Kuhl . Heiner . Strassert . Jürgen F.H. . Čertnerová . Dora . Varga . Elisabeth . Kreuz . Eva . Lamatsch . Dunja K. . Wuertz . Sven . Köhler . Jan . Monaghan . Michael T. . Stöck . Matthias . The haplotype-resolved Prymnesium parvum (type B) microalga genome reveals the genetic basis of its fish-killing toxins . Current Biology . Elsevier BV . 2024 . 0960-9822 . 10.1016/j.cub.2024.06.033 . free .
3. Fallon . Timothy R. . Shende . Vikram V. . Wierzbicki . Igor H. . Pendleton . Amanda L. . Watervoort . Nathan F. . Auber . Robert P. . Gonzalez . David J. . Wisecaver . Jennifer H. . Moore . Bradley S. . Giant polyketide synthase enzymes in the biosynthesis of giant marine polyether toxins . Science . 385 . 6709 . 2024-08-09 . 0036-8075 . 10.1126/science.ado3290 . 671–678.