Prunetin Explained

Prunetin is an O-methylated isoflavone, a type of flavonoid. It has been isolated for the first time by Finnemore in 1910 in the bark of Prunus emarginata (the Oregon cherry).^[1] Prunetin isolated from pea roots can act as an attractant for Aphanomyces euteiches zoospores.^[2] It is also an allosteric inhibitor of human liver aldehyde dehydrogenase.^[3]

Prunetin can lower blood pressure of spontaneously hypertensive rats and relax isolated rat aortic rings through calcium channel block mechanisms in vessel smooth muscles.^[4]

Glycosides

• 8-C-glucosyl prunetin, isolated from the leaves of Dalbergia hainanensis^[5]

See also

• List of phytochemicals in food
• Biochanin A

Notes and References

1. 10.1021/jo01180a006 . 10 . 4 . 1945 . The Journal of Organic Chemistry . 288–291 . Shriner . R. L. . Hull . Clarence J.. Isoflavones. III. The Structure of Prunetin and a New Synthesis of Genistein1 .
2. Yokosawa . Ryozo . Kuninaga . Shiro . Sekizaki . Harua . 1986 . Aphanomyces euteiches zoospore attractant isolated from pea root; prunetin . Ann. Phytopath. Soc. Japan . 52 . 5. 809–816 . 10.3186/jjphytopath.52.809 . free .
3. Sheikh . S. . Weiner . H. . 1997 . Allosteric inhibition of human liver aldehyde dehydrogenase by the isoflavone prunetin . . 53 . 4. 471–478 . 10.1016/s0006-2952(96)00837-4. 9105397 .
4. Kim, B., Jo, C., Choi, H. Y., & Lee, K. (2018). "Prunetin relaxed isolated rat aortic rings by blocking calcium channels". Molecules, 23(9), 2372.
5. http://www.imm.ac.cn/journal/ccl/1307/130717-645-01-587-p4.pdf Conformational Study of 8-C-glucosyl-prunetin by Dynamic NMR Spectroscopy. Pei Cheng Zhang, Ying Hong Wang, Xin Liu, Xiang Yi, Ruo Yun Chen and De Quan Yu, Chinese Chemical Letters Vol. 13, No. 7, pp 645 – 648, 2002