| Prudenciana C. Cruz | |
| Birth Name: | Prudenciana Dumagan Comiling |
| Birth Date: | May 19, 1943 |
| Birth Place: | Alburquerque, Bohol, Commonwealth of the Philippines |
| Director of the National Library of the Philippines | |
| Alma Mater: | University of San Carlos University of the Philippines Diliman |
| Occupation: | Librarian |
| Spouse: | Rodrigo A. Cruz |
Prudenciana Comiling Cruz (born Prudenciana Dumagan Comiling; May 19, 1943) is the sixteenth director of the National Library of the Philippines, having acceded to the position on December 7, 2001. She is affectionately called "Nani" by both patrons and staff of the National Library, alluding to her motherly qualities and her use of these qualities in running the library.
Cruz was born in Alburquerque, Bohol on May 19, 1943, the second of four children born to Dionisio Comiling and Victoriano Dumagan. She graduated from the University of San Carlos in Cebu City majoring in library science, and later on completing her graduate studies at the University of the Philippines Diliman.
Cruz began her career as a librarian in 1964 at the Divine Word College of Tagbilaran (presently Holy Name University), where she served as chief librarian. In 1970, she became senior librarian of the Bohol Provincial Library, and later on joined the ranks of the National Library of the Philippines. She was appointed director of the National Library by President Gloria Macapagal Arroyo on December 7, 2001, at the recommendation of her predecessor, Adoracion B. Mendoza, to whom she served as assistant director.
During her tenure as director of the National Library, she has served as head of the steering committee in charge of the Philippine eLibrary. In addition, the Children's Library and the Philippine President's Room of the Filipiniana Division were opened in 2007.
Cruz is married to Rodrigo A. Cruz, a retired expert on livestock production. They have three children and three grandchildren.