Protonitazene Explained

Drug Name:Protonitazene
Legal Br:F1
Legal Uk:PSA
Legal Us:Schedule I
Legal De:Anlage II
C:23
H:30
N:4
O:3
Iupac Name:N,N-diethyl-2-[5-nitro-2-[(4-propoxyphenyl)methyl]benzimidazol-1-yl]ethanamine
Cas Number:95958-84-2
Pubchem:156589001
Unii:4A6RZQ7M2V
Kegg:C22683
Smiles:CCCOC1=CC=C(C=C1)CC2=NC3=C(N2CCN(CC)CC)C=CC(=C3)[N+](=O)[O-]
Stdinchi:1S/C23H30N4O3/c1-4-15-30-20-10-7-18(8-11-20)16-23-24-21-17-19(27(28)29)9-12-22(21)26(23)14-13-25(5-2)6-3/h7-12,17H,4-6,13-16H2,1-3H3
Stdinchikey:SJHUJFHOXYDSJY-UHFFFAOYSA-N

Protonitazene is a benzimidazole derivative with potent opioid effects which has been sold over the internet as a designer drug since 2019, and has been identified in various European countries, as well as Canada, the US and Australia.[1] It has been linked to numerous cases of drug overdose, and is a Schedule I drug in the US.[2] [3] [4] [5] [6]

It was developed by a Swiss pharmaceutical company in the 1950s as an alternative to morphine, but was never adopted due to severe side effects.[7]

See also

Notes and References

  1. Edinoff AN, Martinez Garza D, Vining SP, Vasterling ME, Jackson ED, Murnane KS, Kaye AM, Fair RN, Torres YJ, Badr AE, Cornett EM, Kaye AD . New Synthetic Opioids: Clinical Considerations and Dangers . Pain and Therapy . 12 . 2 . 399–421 . April 2023 . 36826742 . 9950705 . 10.1007/s40122-023-00481-6 .
  2. Schumann JL, Syrjanen R, Alford K, Mashetty S, Castle JW, Rotella J, Maplesden J, Greene SL . 6 . Intoxications in an Australian Emergency Department Involving 'Nitazene' Benzylbenzimidazole Synthetic Opioids (Etodesnitazene, Butonitazene and Protonitazene) . Journal of Analytical Toxicology . August 2022 . 47 . 1 . e6–e9 . 35983900 . 10.1093/jat/bkac062 .
  3. Kanamori T, Okada Y, Segawa H, Yamamuro T, Kuwayama K, Tsujikawa K, Iwata YT . Analysis of highly potent synthetic opioid nitazene analogs and their positional isomers . Drug Testing and Analysis . November 2022 . 15 . 4 . 449–457 . 36437623 . 10.1002/dta.3415 . 254042990 .
  4. Papsun DM, Krotulski AJ, Logan BK . Proliferation of Novel Synthetic Opioids in Postmortem Investigations After Core-Structure Scheduling for Fentanyl-Related Substances . The American Journal of Forensic Medicine and Pathology . 43 . 4 . 315–327 . December 2022 . 36103391 . 10.1097/PAF.0000000000000787 . 252220135 .
  5. Walton SE, Krotulski AJ, Logan BK . A Forward-Thinking Approach to Addressing the New Synthetic Opioid 2-Benzylbenzimidazole Nitazene Analogs by Liquid Chromatography-Tandem Quadrupole Mass Spectrometry (LC-QQQ-MS) . Journal of Analytical Toxicology . 46 . 3 . 221–231 . March 2022 . 34792157 . 10.1093/jat/bkab117 . 8935987 .
  6. 21 CFR Part 1308. [Docket No. DEA–900] Schedules of Controlled Substances: Temporary Placement of Butonitazene, Etodesnitazene, Flunitazene, Metodesnitazene, Metonitazene, N-Pyrrolidino etonitazene, and Protonitazene in Schedule I. ]. Drug Enforcement Administration . Federal Register . 12 April 2022 . 87 . 70 . 21556 .
  7. Web site: Faugstad . Sebastian . 23 November 2022 . 20-åring døde etter inntak av nytt, livsfarlig rusmiddel . 20-year-old died after consuming a new, life-threatening drug . 26 July 2023 . . nb-NO . Protonitazen er et syntetisk opioid som ble utviklet av et sveitsisk legemiddelselskap på 50-tallet. Det var ment som et alternativ til morfin, men på grunn av alvorlige bivirkninger ble stoffet aldri tatt i bruk. . Protonitazen is a synthetic opioid that was developed by a Swiss pharmaceutical company in the 50s. It was intended as an alternative to morphine, but due to severe side effects, the drug was never used..

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