Prothipendyl Explained

Prothipendyl (brand names Dominal, Timovan, Tolnate), also known as azapromazine or phrenotropin, is an anxiolytic, antiemetic, and antihistamine of the azaphenothiazine group which is marketed in Europe and is used to treat anxiety and agitation in psychotic syndromes.^{[1] [2] [3] [4]} It differs from promazine only by the replacement of one carbon atom with a nitrogen atom in the tricyclic ring system. Prothipendyl is said to not possess antipsychotic effects, and in accordance, appears to be a weaker dopamine receptor antagonist than other phenothiazines.^[5]

Synthesis

See also: Pipazetate.1-Azaphenothiazine [261-96-1] (1)3-Dimethylaminopropyl chloride [109-54-6] (2)Sodium hydride suspension

Notes and References

1. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1038–.
2. Book: Index Nominum 2000: International Drug Directory. 2000. Taylor & Francis. 978-3-88763-075-1. 893–.
3. Web site: Archived copy . 2017-09-27 . 2017-09-27 . https://web.archive.org/web/20170927160324/https://www.drugs.com/international/prothipendyl.html . dead .
4. Book: D. Leigh. C.M. Pare. J. Marks. A Concise Encyclopaedia of Psychiatry. 6 December 2012. Springer Science & Business Media. 978-94-011-5913-5. 396–.
5. Book: Psychotropic Agents: Part I: Antipsychotics and Antidepressants. 6 December 2012. Springer Science & Business Media. 978-3-642-67538-6. 131–.