Protein wntless homolog explained

Protein wntless homolog, commonly known as Wntless, is encoded in humans by the WLS gene .[1] Wntless is a receptor for Wnt proteins in Wnt-secreting cells.[2]

Wntless was shown to be a cargo for the retromer complex. It has been found essential for hair follicle induction.[3]

A homozygous missense mutation in the WLS gene was identified in Zaki syndrome.[4]

Further reading

Notes and References

  1. Web site: WLS - Protein wntless homolog - Homo sapiens (Human) - WLS gene & protein . www.uniprot.org . 30 May 2022 . en.
  2. Eaton S . Retromer retrieves wntless . Developmental Cell . 14 . 1 . 4–6 . January 2008 . 18194646 . 10.1016/j.devcel.2007.12.014 . free .
  3. Fu J, Hsu W . Epidermal Wnt controls hair follicle induction by orchestrating dynamic signaling crosstalk between the epidermis and dermis . The Journal of Investigative Dermatology . 133 . 4 . 890–8 . April 2013 . 23190887 . 3594635. 10.1038/jid.2012.407 .
  4. Chai. Guoliang. Szenker-Ravi. Emmanuelle. Chung. Changuk. Li. Zhen. Wang. Lu. Khatoo. Muznah. Marshall. Trevor. Jiang. Nan. Yang. Xiaoxu. McEvoy-Venneri. Jennifer. Stanley. Valentina. 2021-09-29. A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. New England Journal of Medicine. 385 . 14 . 1292–1301 . en. 10.1056/NEJMoa2033911. 34587386 . 9017221 .