Protein BTG4 explained

Protein BTG4 also known as BTG family member 4 is a protein that in humans is encoded by the BTG4 gene (B-cell translocation gene 4).^{[1] [2]} BTG4 has anti-proliferative properties and can induce G₁ cell cycle arrest.^[2]

Further reading

• Auer RL, Starczynski J, McElwaine S . Identification of a potential role for POU2AF1 and BTG4 in the deletion of 11q23 in chronic lymphocytic leukemia. . Genes Chromosomes Cancer . 43 . 1 . 1–10 . 2005 . 15672409 . 10.1002/gcc.20159 . 34431756 . etal.
• Strausberg RL, Feingold EA, Grouse LH . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241. 2002PNAS...9916899M . etal. free .
• Dong W, Tu S, Xie J . Frequent promoter hypermethylation and transcriptional downregulation of BTG4 gene in gastric cancer. . Biochem. Biophys. Res. Commun. . 387 . 1 . 132–8 . 2009 . 19576178 . 10.1016/j.bbrc.2009.06.140 . 5602860 . etal.
• Yoshida Y, Hosoda E, Nakamura T, Yamamoto T . Association of ANA, a member of the antiproliferative Tob family proteins, with a Caf1 component of the CCR4 transcriptional regulatory complex. . Jpn. J. Cancer Res. . 92 . 6 . 592–6 . 2001 . 11429045 . 5926753 . 10.1111/j.1349-7006.2001.tb01135.x.
• Toyota M, Suzuki H, Sasaki Y . Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. . Cancer Res. . 68 . 11 . 4123–32 . 2008 . 18519671 . 10.1158/0008-5472.CAN-08-0325 . etal. free .
• Tirone F . The gene PC3(TIS21/BTG2), prototype member of the PC3/BTG/TOB family: regulator in control of cell growth, differentiation, and DNA repair? . J. Cell. Physiol. . 187 . 2 . 155–65 . 2001 . 11267995 . 10.1002/jcp.1062 . 83558340 . free .

Notes and References

1. Web site: Entrez Gene: B-cell translocation gene 4.
2. Buanne P, Corrente G, Micheli L, Palena A, Lavia P, Spadafora C, Lakshmana MK, Rinaldi A, Banfi S, Quarto M, Bulfone A, Tirone F . Cloning of PC3B, a novel member of the PC3/BTG/TOB family of growth inhibitory genes, highly expressed in the olfactory epithelium . Genomics . 68 . 3 . 253–63 . September 2000 . 10995567 . 10.1006/geno.2000.6288 .