Protein AATF explained

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.^{[1] [2] [3]}

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.^[3]

Interactions

Protein AATF has been shown to interact with:

• PAWR,^[4]
• POLR2J,^[2]
• Retinoblastoma protein,^{[2] [5]} and
• Transcription factor Sp1.^[6]

Further reading

• Page G, Lödige I, Kögel D, Scheidtmann KH . AATF, a novel transcription factor that interacts with Dlk/ZIP kinase and interferes with apoptosis . FEBS Letters . 462 . 1–2 . 187–91 . Nov 1999 . 10580117 . 10.1016/S0014-5793(99)01529-X . 6061613 . free .
• Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H, Mann M, Lamond AI . Directed proteomic analysis of the human nucleolus . Current Biology . 12 . 1 . 1–11 . Jan 2002 . 11790298 . 10.1016/S0960-9822(01)00650-9 . 14132033 . free . 2002CBio...12....1A .
• Scherl A, Couté Y, Déon C, Callé A, Kindbeiter K, Sanchez JC, Greco A, Hochstrasser D, Diaz JJ . Functional proteomic analysis of human nucleolus . Molecular Biology of the Cell . 13 . 11 . 4100–9 . Nov 2002 . 12429849 . 133617 . 10.1091/mbc.E02-05-0271 .
• Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M . Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb . Cancer Cell . 2 . 5 . 387–99 . Nov 2002 . 12450794 . 10.1016/S1535-6108(02)00182-4 . free .
• Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M . Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter . The Journal of Biological Chemistry . 278 . 38 . 36496–504 . Sep 2003 . 12847090 . 10.1074/jbc.M306694200 . free .
• Guo Q, Xie J . AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 . The Journal of Biological Chemistry . 279 . 6 . 4596–603 . Feb 2004 . 14627703 . 10.1074/jbc.M309811200 . free .
• Barbato C, Corbi N, Canu N, Fanciulli M, Serafino A, Ciotti M, Libri V, Bruno T, Amadoro G, De Angelis R, Calissano P, Passananti C . Rb binding protein Che-1 interacts with Tau in cerebellar granule neurons. Modulation during neuronal apoptosis . Molecular and Cellular Neurosciences . 24 . 4 . 1038–50 . Dec 2003 . 14697667 . 10.1016/j.mcn.2003.08.002 . 2108/56917 . 35111183 . free .
• Burgdorf S, Leister P, Scheidtmann KH . TSG101 interacts with apoptosis-antagonizing transcription factor and enhances androgen receptor-mediated transcription by promoting its monoubiquitination . The Journal of Biological Chemistry . 279 . 17 . 17524–34 . Apr 2004 . 14761944 . 10.1074/jbc.M313703200 . free .
• Xie J, Guo Q . AATF protects neural cells against oxidative damage induced by amyloid beta-peptide . Neurobiology of Disease . 16 . 1 . 150–7 . Jun 2004 . 15207272 . 10.1016/j.nbd.2004.02.003 . 53204920 .
• Lehner B, Sanderson CM . A protein interaction framework for human mRNA degradation . Genome Research . 14 . 7 . 1315–23 . Jul 2004 . 15231747 . 442147 . 10.1101/gr.2122004 .
• Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M . Nucleolar proteome dynamics . Nature . 433 . 7021 . 77–83 . Jan 2005 . 15635413 . 10.1038/nature03207 . 2005Natur.433...77A . 4344740 .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proceedings of the National Academy of Sciences of the United States of America . 103 . 14 . 5391–6 . Apr 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .
• Kaul D, Mehrotra A . Functional characterization of AATF transcriptome in human leukemic cells . Molecular and Cellular Biochemistry . 297 . 1–2 . 215–20 . Mar 2007 . 17006618 . 10.1007/s11010-006-9317-1 . 8612000 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Lindfors K, Halttunen T, Huotari P, Nupponen N, Vihinen M, Visakorpi T, Mäki M, Kainulainen H . Identification of novel transcription factor-like gene from human intestinal cells . Biochemical and Biophysical Research Communications . 276 . 2 . 660–6 . Sep 2000 . 11027528 . 10.1006/bbrc.2000.3480 .
2. Fanciulli M, Bruno T, Di Padova M, De Angelis R, Iezzi S, Iacobini C, Floridi A, Passananti C . Identification of a novel partner of RNA polymerase II subunit 11, Che-1, which interacts with and affects the growth suppression function of Rb . FASEB Journal . 14 . 7 . 904–12 . May 2000 . 10783144 . 10.1096/fasebj.14.7.904. free . 43175069 .
3. Web site: Entrez Gene: AATF apoptosis antagonizing transcription factor.
4. Guo Q, Xie J . AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4 . The Journal of Biological Chemistry . 279 . 6 . 4596–603 . Feb 2004 . 14627703 . 10.1074/jbc.M309811200 . free .
5. Bruno T, De Angelis R, De Nicola F, Barbato C, Di Padova M, Corbi N, Libri V, Benassi B, Mattei E, Chersi A, Soddu S, Floridi A, Passananti C, Fanciulli M . Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb . Cancer Cell . 2 . 5 . 387–99 . Nov 2002 . 12450794 . 10.1016/s1535-6108(02)00182-4. Fanciulli Maurizio . Passananti Claudio . free .
6. Di Padova M, Bruno T, De Nicola F, Iezzi S, D'Angelo C, Gallo R, Nicosia D, Corbi N, Biroccio A, Floridi A, Passananti C, Fanciulli M . Che-1 arrests human colon carcinoma cell proliferation by displacing HDAC1 from the p21WAF1/CIP1 promoter . The Journal of Biological Chemistry . 278 . 38 . 36496–504 . Sep 2003 . 12847090 . 10.1074/jbc.M306694200 . free .