Protein-fructosamine 3-kinase explained

Protein-fructosamine 3-kinase
Ec Number:	2.7.1.171

Protein-fructosamine 3-kinase (FN3K, fructosamine 3-kinase) is an enzyme with systematic name ATP:(protein)-N⁶-D-fructosyl-L-lysine 3-phosphotransferase.^{[1] [2]} This enzyme catalyses the following chemical reaction

ATP + [protein]-N⁶-D-fructosyl-L-lysine

\rightleftharpoons ADP + [protein]-N⁶-(3-O-phospho-D-fructosyl)-L-lysine

Nonenzymatic glycation is a factor in the pathogenesis of diabetes.

Notes and References

1. Szwergold BS, Howell S, Beisswenger PJ . Human fructosamine-3-kinase: purification, sequencing, substrate specificity, and evidence of activity in vivo . Diabetes . 50 . 9 . 2139–47 . September 2001 . 11522682 . 10.2337/diabetes.50.9.2139 . free .
2. Delpierre G, Rider MH, Collard F, Stroobant V, Vanstapel F, Santos H, Van Schaftingen E . Identification, cloning, and heterologous expression of a mammalian fructosamine-3-kinase . Diabetes . 49 . 10 . 1627–34 . October 2000 . 11016445 . 10.2337/diabetes.49.10.1627 .