| protein-arginine deiminase | |
| Ec Number: | 3.5.3.15 |
| Cas Number: | 75536-80-0 |
| Go Code: | 0004668 |
| Width: | 270 |
In enzymology, a protein-arginine deiminase is an enzyme that catalyzes a form of post translational modification called arginine de-imination or citrullination:
protein L-arginine + H2O
\rightleftharpoons
Thus, the two substrates of this enzyme are protein L-arginine (arginine residue inside a protein) and H2O, whereas its two products are protein L-citrulline and NH3:
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amidines. The systematic name of this enzyme class is protein-L-arginine iminohydrolase. This enzyme is also called peptidylarginine deiminase.
As of late 2007, seven structures have been solved for this class of enzymes, with PDB accession codes,,,,,, and .
Mammals have 5 protein-arginine deiminases, with symbols
except for rodents, there the letter case is different:
The different case is just a historical artifact. It doesn't indicate that the rodent proteins are special.