Protease-sparing regimen explained

Protease-sparing regimen
Synonym:	PSR
Specialty:	virology

Protease-sparing regimen, often abbreviated as PSR, is a method or therapy for treating people infected with HIV that involves a three-drug combination that reduces viral load below the limit of detection while saving protease inhibitors for later use. It is considered a weaker (in terms of quantity and concentration) form of HIV treatment. It has been argued that such a regimen is not as potent as giving HIV patients with the strongest drugs as soon as it is detected. Others believe that this might be considered a long-term strategy in order to reduce the amount of HIV,^[1] and in some instances have proven to be successful.^[2]

See also

• Protease
• Women's Interagency HIV Study

External links

• Protease Sparing Regimen in a Real Life Practice with Naive Patients: An Equal Opportunity Approach? . 13th International AIDS Conference . July 9–14, 2000 . Durban, South Africa . WePeB4134 . 2007-04-17 . https://web.archive.org/web/20070930182857/http://www.aegis.com/conferences/iac/2000/WePeB4134.html . 2007-09-30 . dead .
• http://www.aids-ed.org/aidsetc?page=et-14-00-02
• http://www.medscape.com/viewarticle/418668

Notes and References

1. Corales RB, Shrestha NK, Taege AJ, etal . Protease-sparing regimen in a real-life practice with naïve patients: an equal opportunity approach? . HIV Clin Trials . 2 . 1 . 17–21 . 2001 . 11590510 . 10.1310/2V0B-HDWC-AGWR-H56M . 26663673 .
2. Van der Linden D, Hainaut M, Goetghebuer T, etal . Effectiveness of early initiation of protease inhibitor-sparing antiretroviral regimen in human immunodeficiency virus-1 vertically infected infants . Pediatr. Infect. Dis. J. . 26 . 4 . 359–61 . April 2007 . 17414406 . 10.1097/01.inf.0000258626.34984.eb . 2078/119175 . 74548567 . free .