Prostaglandin E synthase explained

prostaglandin-E synthase
Ec Number:	5.3.99.3
Cas Number:	52227-79-9
Go Code:	0050220

Prostaglandin E synthase (or PGE synthase) is an enzyme involved in eicosanoid and glutathione metabolism, a member of MAPEG family. It generates prostaglandin E (PGE) from prostaglandin H2.^{[1] [2]}

The synthase generating PGE2 is a membrane-associated protein.

Isozymes

Humans express three prostaglandin-E synthase isozymes, each encoded by a separate gene:

Notes and References

1. Murakami M, Nakatani Y, Tanioka T, Kudo I . Prostaglandin E synthase . Prostaglandins Other Lipid Mediat. . 68-69 . 383–99 . August 2002 . 12432931 . 10.1016/S0090-6980(02)00043-6. 22246484 .
2. Park JY, Pillinger MH, Abramson SB . Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases . Clin. Immunol. . 119 . 3 . 229–40 . June 2006 . 16540375 . 10.1016/j.clim.2006.01.016 .