| Prosser Hollow Brook | |
| Pushpin Map: | New York |
| Pushpin Map Caption: | Location of the mouth of Prosser Hollow Brook |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New York |
| Subdivision Type4: | County |
| Subdivision Name4: | Delaware |
| Source1 Coordinates: | 42.4235°N -74.9484°W |
| Mouth: | Charlotte Creek |
| Mouth Coordinates: | 42.4413°N -74.9895°W |
Prosser Hollow Brook is a river in Delaware County, New York. It flows into Charlotte Creek west-southwest of Davenport Center.