Propanamide Explained

Propanamide has the chemical formula CH₃CH₂C=O(NH₂).^[1] It is the amide of propanoic acid.

This organic compound is a mono-substituted amide.^[2] Organic compounds of the amide group can react in many different organic processes to form other useful compounds for synthesis.

Preparation

Propanamide can be prepared by the condensation reaction between urea and propanoic acid:

(NH2)2CO + 2CH3CH2COOH -> CH3CH2CO(NH2) + H2O + CO2

or by the dehydration of ammonium propionate:

(NH4)CH3CH2COO -> CH3CH2CONH2 + H2O

Reactions

Propanamide being an amide can participate in a Hofmann rearrangement to produce ethylamine gas.

Notes and References

1. Ramazani . Ali . Rouhani . Morteza . Joo . Sang Woo . 2016-01-01 . Catalyst-free sonosynthesis of highly substituted propanamide derivatives in water . Ultrasonics Sonochemistry . en . 28 . 393–399 . 10.1016/j.ultsonch.2015.08.019 . 26384923 . 1350-4177. free .
2. Ye . Xuewei . Chai . Weiyun . Lian . Xiao-Yuan . Zhang . Zhizhen . 2017-06-18 . Novel propanamide analogue and antiproliferative diketopiperazines from mangrove Streptomyces sp. Q24 . Natural Product Research . 31 . 12 . 1390–1396 . 10.1080/14786419.2016.1253079 . 1478-6419 . 27806640. 24563632 . subscription .