Propentofylline Explained

Propentofylline (HWA 285) is a xanthine derivative drug with purported neuroprotective effects.

Pharmacology

It is a phosphodiesterase inhibitor,^[1] and also acts as an adenosine reuptake inhibitor.^{[1] [2] [3]}

Uses

Propentofylline was studied as a possible treatment for Alzheimer's disease and multi-infarct dementia,^[4] and has been studied, to a lesser extent, as a possible adjunct in the treatment of ischemic stroke, due to its vasodilating properties.^{[5] [6]}

Propentofylline is in use as a veterinary medicine in older dogs.^[7]

See also

• Pentoxifylline

External links

• Summary of research, including possible multipartite mechanisms

Notes and References

1. Frampton M, Harvey RJ, Kirchner V . Propentofylline for dementia . The Cochrane Database of Systematic Reviews . 2 . CD002853 . 2003 . 12804440 . 10.1002/14651858.CD002853 . Frampton MA .
2. Salimi S, Fotouhi A, Ghoreishi A, Derakhshan MK, Khodaie-Ardakani MR, Mohammadi MR, Noorbala AA, Ahmadi-Abhari SA, Hajiazim M, Abbasi SH, Akhondzadeh S . 6 . A placebo controlled study of the propentofylline added to risperidone in chronic schizophrenia . Progress in Neuro-Psychopharmacology & Biological Psychiatry . 32 . 3 . 726–732 . April 2008 . 18096287 . 10.1016/j.pnpbp.2007.11.021 . vanc . 21498202 .
3. Numagami Y, Marro PJ, Mishra OP, Delivoria-Papadopoulos M . Effect of propentofylline on free radical generation during cerebral hypoxia in the newborn piglet . Neuroscience . 84 . 4 . 1127–1133 . June 1998 . 9578400 . 10.1016/S0306-4522(97)00542-3 . 36155779 . free .
4. Kittner B, Rössner M, Rother M . Clinical trials in dementia with propentofylline . Annals of the New York Academy of Sciences . 826 . 1 . 307–316 . September 1997 . 9329701 . 10.1111/j.1749-6632.1997.tb48481.x . 12493243 . 1997NYASA.826..307K .
5. Bath PM, Bath-Hextall FJ . Pentoxifylline, propentofylline and pentifylline for acute ischaemic stroke . The Cochrane Database of Systematic Reviews . 3 . CD000162 . 2004 . 15266424 . 10.1002/14651858.CD000162.pub2 . Bath PM .
6. Huber M, Kittner B, Hojer C, Fink GR, Neveling M, Heiss WD . Effect of propentofylline on regional cerebral glucose metabolism in acute ischemic stroke . Journal of Cerebral Blood Flow and Metabolism . 13 . 3 . 526–530 . May 1993 . 8478410 . 10.1038/jcbfm.1993.68 . 24909748 .
7. News: Yorkshire Post. 7 September 2012. Launch of tablet to make life easier for dogs in old age. 28 December 2019.