Propazepine Explained

Propazepine is a tricyclic antidepressant (TCA).^[1] Propazepine is sometimes confused with imipramine, which has the central ring nitrogen in a different location. Prazepine is the International nonproprietary name of this compound.^[2] Prazepine is also reported to be one of the many synonyms of imipramine.^[3] Propazepine can be synthesized chemically.^{[4] [5]} Propazepine appears to never have actually been used as a tricyclic antidepressant outside of initial medical tests; therefore, there is little information about it.

Further reading

• 5457443. 1970. Vojtechovsky. M. The influence of propazepine on learning and memory in healthy volunteers and in patients with slight chronic brain syndrome. Activitas Nervosa Superior. 12. 3. 251–2. Safratova. V. Soukupova. B. Czech. 0001-7604.
• 5882104. 1965. Rysánek. K. Serotonin level in human and animal thrombocytes after imipramine and propazepine administration. Activitas Nervosa Superior. 7. 3. 261–2. Vítek. V. Svehla. C. Czech. 0001-7604.
• 14179381. 1964. Souskova. M. Effect of Iproniazid, Propazepine, Reserpine and Their Combinations on the Orientation Reaction and Conditioned Defense Reaction in Rats. Activitas Nervosa Superior. 6. 258–67. Votava. Z. Roth. Z. Czech. 0001-7604.
• 13926058. 1962. Vinarova. M. Blind comparison of clinical effects of Imipramine and Propazepine. Activitas Nervosa Superior. 4. 227–8. Nahunek. K. Vencovsky. E. Bast Ecky. J. Hadlik. J. Czech. 0001-7604.
• 13915453. 1962. Souskova. M. Comparative studies on the effect of Imipramine and Propazepine by a conditioned reflex method in rats. Activitas Nervosa Superior. 4. 218–9. Votava. Z. Czech. 0001-7604.
• 13867184. 1962. Benesova. O. Comparative studies on the effect of Imipramine and Propazepine by electrophysiological methods on animals with implanted electrodes. Activitas Nervosa Superior. 4. 215–6. Bohdanecky. Z. Votava. Z. Czech. 0001-7604.
• 14473038. 1961. Metysova. J. Comparison of pharmacological properties of propazepine and imipramine. Activitas Nervosa Superior. 3. 227. Votava. Z. Czech. 0001-7604.

Notes and References

1. 10.1007/BF00411159. Electrophysiological comparison of the action of imipramine and propazepine. Psychopharmacologia. 3. 6. 423–431. 13967414. 1962. Benešová. O.. Bohdanecký. Z.. Votava. Z.. 1109255.
2. Web site: Propazepine – C19H24N2. Pubchem.
3. Web site: Imipramine – C19H24N2 . ChemSpider.
4. 10.1021/jm00325a016. 14287270. Derivatives of Morphanthridine. Journal of Medicinal Chemistry. 8. 74–80. 1965. Werner. L. H.. Ricca. S.. Mohacsi. E.. Rossi. A.. Arya. V. P..
5. 10.1135/cccc19650445. Neurotrope und psychotrope substanzen II. Morphanthridin und derivate. Neue synthese des propazepins. Collection of Czechoslovak Chemical Communications. 30. 2. 445–462. 1965. Jílek. J. O.. Pomykáček. J.. Svátek. E.. Seidlová. V.. Rajšner. M.. Pelz. K.. Hoch. B.. Protiva. M.. Neurotropic and psychotropic substances II. Morphanthridin and derivatives. New Synthesis of propazepins. Czech.