Proligestone Explained

Proligestone, sold under the brand names Covinan and Delvosteron, is a progestin medication which is used in veterinary medicine.^{[1] [2] [3]}

Uses

Veterinary

Proligestone is used to control estrus in dogs and cats and has also been used to treat hypersexuality in dogs and cats.^[4]

Pharmacology

Pharmacodynamics

Proligestone is a progestogen, or an agonist of the progesterone receptor (PR).

Chemistry

See also: List of progestogens.

Proligestone, also known as 14α,17α-propylidenedioxyprogesterone or as 14α,17α-dihydroxyprogesterone cyclic acetal with propionaldehyde, as well as 14α,17α-propylidenedioxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. It is a C14α,17α cyclic ketal of 14α,17α-dihydroxyprogesterone.^{[5] [6] [7]}

History

Proligestone was described as early as 1968 and was introduced for veterinary use in 1975.^{[8] [9]}

Society and culture

Generic names

Proligestone is the generic name of the drug and its and .

Brand names

Proligestone is marketed under the brand names Covinan and Delvosteron.

Availability

Proligestone is or has been available for veterinary use in Argentina, Australia, Austria, Belgium, Czechoslovakia, France, Germany, Ireland, Italy, the Netherlands, New Zealand, Poland, South Africa, Switzerland, and the United Kingdom.

Notes and References

1. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1025–.
2. Book: Index Nominum 2000: International Drug Directory. January 2000. Taylor & Francis. 978-3-88763-075-1. 882–.
3. Web site: List of Progestins . Drugs.com .
4. Indications for proligestone (Delvosteron) in dogs and cats. Praktische Tierarzt. 22 April 1981. 62. 12. Mundt S .
5. Book: Marler EE . Pharmacological and Chemical Synonyms: A Collection of Names of Drugs, Pesticides and Other Compounds Drawn from the Medical Literature of the World. 1976. Excerpta Medica. 978-90-219-0298-2. 376.
6. Book: Negwer M, Scharnow HG . Organic-chemical drugs and their synonyms: (an international survey). 4 October 2001. Wiley-VCH. 978-3-527-30247-5. 2569.
7. Web site: Proligestone . Medical Subject Headings: Supplementary chemical records . U.S. National Library of Medicine .
8. Book: Official Gazette of the United States Patent and Trademark Office: Trademarks. 1984. U.S. Department of Commerce, Patent and Trademark Office. 30.
9. Vanos JL, Oldenkamp EP . Oestrus control in bitches with proligestone, a new progestational steroid . The Journal of Small Animal Practice . 19 . 9 . 521–529 . September 1978 . 567718 . 10.1111/j.1748-5827.1978.tb05534.x .