Prolame Explained

Prolame, also known as 17β-((3-hydroxypropyl)amino)estradiol, is a synthetic, steroidal estrogen and a 17β-aminoestrogen with anticoagulant effects that was first described in 1985 but was never marketed.^{[1] [2] [3] [4] [5]}

Notes and References

1. Book: J. Elks. The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 1025–.
2. Fernández JM, Rubio-Arroyo MF, Soriano-García M, Toscano RA, Pérez-César MC . Synthesis and molecular structure of prolame, N-(3-hydroxy-1,3,5(10)-estratrien-17 beta-yl)-3-hydroxypropylamine; an amino-estrogen with prolonged anticoagulant and brief estrogenic effects . Steroids . 45 . 2 . 151–7 . 1985 . 3841424 . 10.1016/0039-128x(85)90044-3. 45993880 .
3. Rubio-Póo C, Mandoki JJ, Mendoza-Patiño N, Lemini C, de la Peña A, Cruz F, Zavala E, Silva G, Garcia-Mondragón J, Fernández JM . The anticoagulant effect of prolame, N-(3-hydroxy-1,3,5(10)estratrien-17 beta-yl)-3-hydroxypropylamine, a novel amino-estrogen . Steroids . 45 . 2 . 159–70 . 1985 . 3841425 . 10.1016/0039-128x(85)90045-5. 24724648 .
4. Jaimez R, Cooney A, Jackson K, Lemus AE, Lemini C, Cárdenas M, García R, Silva G, Larrea F . In vivo estrogen bioactivities and in vitro estrogen receptor binding and transcriptional activities of anticoagulant synthetic 17beta-aminoestrogens . J. Steroid Biochem. Mol. Biol. . 73 . 1–2 . 59–66 . 2000 . 10822025 . 10.1016/s0960-0760(00)00053-4. 40211307 .
5. Book: Alan D. Michelson. Platelets. 31 December 2012. Academic Press. 978-0-12-387838-0. 314–.