Prokineticin receptor explained

prokineticin receptor 1
Hgncid:4524
Symbol:PROKR1
Altsymbols:GPR73
Entrezgene:10887
Omim:607122
Refseq:NM_138964
Uniprot:Q8TCW9
Chromosome:2
Arm:p
Band:14
prokineticin receptor 2
Hgncid:15836
Symbol:PROKR2
Altsymbols:GPR73L1
Entrezgene:128674
Omim:607123
Refseq:NM_144773
Uniprot:Q8NFJ6
Chromosome:20
Arm:p
Band:12.3

The prokineticin receptor is a G protein-coupled receptor which binds the peptide hormone prokineticin. There are two variants each encoded by a different gene (PROKR1, PROKR2).[1] These receptors mediate gastrointestinal smooth muscle contraction and angiogenesis.

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Notes and References

  1. Lin DC, Bullock CM, Ehlert FJ, Chen JL, Tian H, Zhou QY . Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins/endocrine gland vascular endothelial growth factor . J. Biol. Chem. . 277 . 22 . 19276–80 . 2002 . 11886876 . 10.1074/jbc.M202139200 . free .