Prokineticin Explained
| Prokineticin 1 |
| Caption: | Prokineticin 1[1] |
| Hgncid: | 18454 |
| Symbol: | PROK1 |
| Entrezgene: | 84432 |
| Omim: | 606233 |
| Refseq: | NM_032414 |
| Uniprot: | P58294 |
| Chromosome: | 1 |
| Arm: | p |
| Band: | 21 |
| prokineticin 2 |
| Hgncid: | 18455 |
| Symbol: | PROK2 |
| Entrezgene: | 60675 |
| Omim: | 607002 |
| Refseq: | NM_021935 |
| Uniprot: | Q9HC23 |
| Chromosome: | 3 |
| Arm: | p |
| Band: | 21.1 |
Prokineticin is a secreted protein that potently contracts gastrointestinal smooth muscle.[2]
Recently, prokineticins have been recognized in humans and other vertebrates.[3] They are thought to be involved in several important physiological processes like neurogenesis, tissue development, angiogenesis, and nociception.[3] [4] Other important physiological roles the Bv8/Prokineticins (PKs) are involved in may include cancer, reproduction, and regulating physiological functions that influence circadian rhythms like hormone secretion, ingestive behaviors, and the sleep/wake cycle.[5]
Mutations in the PROK2 (also known as KAL4) gene have been implicated in hypogonadotropic hypogonadism and gynecomastia.[6]
See also
References
- Web site: RCSB Protein Data Bank - Structure Summary for 2KRA - Solution structure of Bv8 .
- Li M, Bullock CM, Knauer DJ, Ehlert FJ, Zhou QY . Identification of two prokineticin cDNAs: recombinant proteins potently contract gastrointestinal smooth muscle . Mol. Pharmacol. . 59 . 4 . 692–8 . 2001 . 11259612 . 10.1124/mol.59.4.692. 1597745 .
- Morales RA, Daly NL, Vetter I, etal . Chemical synthesis and structure of the prokineticin Bv8 . ChemBioChem . 11 . 13 . 1882–8 . September 2010 . 20677202 . 10.1002/cbic.201000330. 32535956 .
- Liu B, Qiao L, Liu K, Piccinni-Ash TJ, Chen ZF. Molecular and neural basis of pleasant touch sensation. Science 2022; 376(6592):483.
- Negri L, Lattanzi R, Giannini E, Melchiorri P . Bv8/Prokineticin proteins and their receptors . Life Sci. . 81 . 14 . 1103–16 . September 2007 . 17881008 . 10.1016/j.lfs.2007.08.011 .
- Narula. Harmeet S.. Carlson. Harold E.. Gynaecomastia—pathophysiology, diagnosis and treatment. Nature Reviews Endocrinology. 10. 11. 2014. 684–698. 1759-5029. 10.1038/nrendo.2014.139. 25112235. 40159424.
