Prohead Explained

A prohead or procapsid is an immature viral capsid structure formed in the early stages of self-assembly of some bacteriophages, including the Caudovirales or tailed bacteriophages.[1] Production and assembly of stable proheads is an essential precursor to bacteriophage genome packaging; this packaging activity can be replicated in vitro.[2] The prohead structure may take a different shape from the head of a mature virion, as seen with the prohead of Bacillus subtilis phage φ29.[3]

Notes and References

  1. Catalano. C. E.. Cue, D. . Feiss, M. . Virus DNA packaging: the strategy used by phage λ. Molecular Microbiology. 1995. 16. 6. 1075–1086. 10.1111/j.1365-2958.1995.tb02333.x. 8577244. free.
  2. Murialdo. H.. Becker, A. . Assembly of Biologically Active Proheads of Bacteriophage Lambda in vitro. Proceedings of the National Academy of Sciences. 1977. 74. 3. 906–910. 10.1073/pnas.74.3.906. 265585. 430525. 1977PNAS...74..906M. free.
  3. Ivanovska. I. L.. Bacteriophage capsids: Tough nanoshells with complex elastic properties. Proceedings of the National Academy of Sciences. 2004. 101. 20. 7600–7605. 10.1073/pnas.0308198101. 15133147. 419652. etal. 2004PNAS..101.7600I. free.

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