Progressive nodular histiocytosis explained

Specialty:Dermatology

Progressive nodular histiocytosis is a cutaneous condition clinically characterized by the development of two types of skin lesions: superficial papules and deeper larger subcutaneous nodules.[1] Progressive nodular histiocytosis was first reported in 1978 by Taunton et al.[2] It is a subclass of non-Langerhans cell histiocytosis and a subgroup of xanthogranuloma.[3]

Signs and symptoms

Progressive nodular histiocytosis most frequently affects young to middle-aged adults who show up with widely distributed, randomly distributed, reddish-brown, cutaneous papules and nodules that are not painful or pruritic.[4] Progressive nodular histiocytosis's clinical course is characterized by an unwavering lack of spontaneous remission.[5] Over time, lesions grow larger and more numerous, and they can cause noticeable disfigurement.[6] [3] Although mucous involvement is possible,[7] internal organs are typically unaffected.[8] Mechanical interference caused by lesions in critical locations, such as the eyelids or the soles of the feet, can result in functional impairment.[8] [9] There is a rare possibility that the cutaneous lesions could cause systemic effects directly; microcytic anemia due to significant intralesional iron sequestration has been documented.[8] Obstructive lesions in the upper airway have been associated with death, despite the fact that they are usually not life-threatening.[9]

Diagnosis

Histologically, it is typified by a diffuse infiltrate of Touton giant cells and xanthomatized histiocytes mixed in with spindle-shaped histiocytes with a whorl-like growth pattern.[3]

Treatment

The primary method of treating progressive nodular histiocytosis is surgical excision.[7] [8] However, a few cases have been reported to have improved following methotrexate administration.[10] Other treatments such as carbon dioxide laser, intralesional as well as systemic steroids,[8] and antineoplastic agents such as imatinib have mostly shown no effect on progressive nodular histiocytosis.[4] Unfortunately, for those who are affected, recurrence is possible even after treatment.[7]

See also

Further reading

External links

Notes and References

  1. Book: James, William D. . Berger, Timothy G. . Andrews' Diseases of the Skin: clinical Dermatology . Saunders Elsevier . 2006 . 978-0-7216-2921-6 . etal.
  2. Taunton . O. David . Progressive Nodular Histiocytoma . Archives of Dermatology . 114 . 10 . 1978-10-01 . 0003-987X . 10.1001/archderm.1978.01640220054014 . 1505. 214042 .
  3. Chuang . Fu-Chen . Chern . Erick . Wu . Wei-Ming . Progressive nodular histiocytosis: a rare type of xanthogranuloma . Dermatologica Sinica . Medknow . 29 . 3 . 2011 . 1027-8117 . 10.1016/j.dsi.2011.07.005 . 98–100. free .
  4. Williams . Abhilasha . Thomas . AbrahamG . Kwatra . KanwardeepSingh . Jain . Kunal . Progressive nodular histiocytosis associated with eale′s disease . Indian Journal of Dermatology . Medknow . 60 . 4 . 2015 . 0019-5154 . 10.4103/0019-5154.160492 . free . 388. 4533540 .
  5. Numbere . Numbereye . Pukhalskaya . Tatsiana . Bowman . Blythe . Campbell . Katelynn . Smoller . Bruce . Progressive Nodular Histiocytosis: Report of a Case and Review of the Literature . Case Reports in Pathology . Hindawi Limited . 2021 . September 17, 2021 . 2090-679X . 10.1155/2021/5531820 . free . 1–6. 34567817 . 8463211 .
  6. Kiyohara . T . Makimura . K . Miyamoto . M . Shijimaya . T . Nagano . N . Nakamaru . S . Tanimura . H . Progressive Nodular Histiocytosis with Large Nodules and a Bulky Mass . Acta Dermato Venereologica . Medical Journals Sweden AB . 99 . 6 . 2019 . 0001-5555 . 10.2340/00015555-3045 . 610–611. 30226532 . free .
  7. Glavin . F. L. . Chhatwall . H. . Karimi . K. . Progressive nodular histiocytosis: a case report with literature review, and discussion of differential diagnosis and classification . Journal of Cutaneous Pathology . Wiley . 36 . 12 . October 26, 2009 . 0303-6987 . 10.1111/j.1600-0560.2009.01454.x . 1286–1292. 19878386 . 22414587 .
  8. Hilker . Olaf . Kovneristy . Alexander . Varga . Rita . Neubert . Thorsten . Wesselmann . Ulrich . Flaig . Michael J. . Ruzicka . Thomas . Burgdorf . Walter . Lehmann . Percy . Progressive nodular histiocytosis . JDDG: Journal der Deutschen Dermatologischen Gesellschaft . Wiley . 11 . 4 . December 11, 2012 . 1610-0379 . 10.1111/j.1610-0387.2012.08069.x . 301–307. 23231636 .
  9. Salunke . Aarti . Belgaumkar . Vasudha . Chavan . Ravindranath . Dobariya . Rinkesh . Laryngeal involvement with fatal outcome in progressive nodular histiocytosis: A rare case report . Indian Dermatology Online Journal . Medknow . 7 . 6 . 2016 . 2229-5178 . 10.4103/2229-5178.193913 . free . 516. 27990389 . 5134168 .
  10. Huet . Flavien . Brenaut . Emilie . Costa . Sebastian . Lemasson . Gilles . Sonbol . Haitham . Misery . Laurent . Progressive nodular histiocytosis improved by methotrexate . European Journal of Dermatology . John Libbey Eurotext . 27 . 6 . 2017 . 1167-1122 . 10.1684/ejd.2017.3115 . 661–663. 29165296 . 21473573 .

This article is licensed under the GNU Free Documentation License. It uses material from the Wikipedia article "Progressive nodular histiocytosis".

Except where otherwise indicated, Everything.Explained.Today is © Copyright 2009-2024, A B Cryer, All Rights Reserved. Cookie policy.