Progestin and adipoQ receptor explained

The progestin and adipoQ receptor (PAQR) family is a group of receptors related to but distinct from the G protein-coupled receptor family, which have the similar seven transmembrane structure, but the N-terminal is located on the inner side of the cell.^[1] It includes at least 11 receptors (PAQR1–PAQR11), including the adiponectin (adipoQ) receptors (AdipoRs), the membrane progesterone receptors (mPRs), and others.

In 2016, the University of Tokyo announced that it would launch an investigation into claims of fabrication of AdipoRs identification data, as accused by an anonymous person/group called Ordinary_researchers.^[2]

List of PAQRs

AdipoRs

• PAQR1 (AdipoR1)
• PAQR2 (AdipoR2)

mPRs

• PAQR5 (mPRγ)
• PAQR6 (mPRδ)
• PAQR7 (mPRα)
• PAQR8 (mPRβ)
• PAQR9 (mPRϵ)

Others

• PAQR3
• PAQR4
• PAQR10
• PAQR11

Notes and References

1. Tang. Y. Tom. Hu. Tianhua. Arterburn. Matthew. Boyle. Bryan. Bright. Jessica M.. Emtage. Peter C.. Funk. Walter D.. PAQR Proteins: A Novel Membrane Receptor Family Defined by an Ancient7-Transmembrane Pass Motif. Journal of Molecular Evolution. 61. 3. 2005. 372–380. 0022-2844. 10.1007/s00239-004-0375-2. 16044242.
2. https://www.science.org/content/article/university-tokyo-investigate-data-manipulation-charges-against-six-prominent-research University of Tokyo to investigate data manipulation charges against six prominent research groups