Proctosedyl Explained

Proctosedyl is the brand name for a family of two products with identical active ingredients designed to treat a variety of proctological disorders. One is a topical ointment, the other a rectal suppository. In the United Kingdom both products are contract manufactured by Patheon Limited on behalf of the Sanofi-Aventis group.[1] [2] Manufacture and distribution is provided by Sanofi Aventis subsidiaries[3] Hoechst and Hoechst Marion Roussel in other territories worldwide.[4]

Application

Both the yellowish-white, translucent, greasy ointment[1] and the smooth, off-white suppositories[2] are formulated for the relief of chronic pruritus ani (otherwise known anal itching or anusitis)[1] [2] [5] and the treatment of pain, irritation, discharge and itching associated with haemorrhoids (otherwise known as piles).[1] [2] [5] However both products are also used to provide pain relief in the treatment of anal fissure,[6] [7] [8] for patients undergoing haemorrhoidectomy, (pre and post-operative),[8] in the relief of post-partum (otherwise known as post-natal) haemorrhoidal conditions,[8] [9] and in the treatment of non-infective proctitis.[8]

Active ingredients

Both preparations contain:

Preparations in some territories may also contain:

External links

Notes and References

  1. Web site: Patient Information Leaflets Online: Proctosedyl Ointment: PL 04425/0207. https://web.archive.org/web/20120220034651/http://xpil.medicines.org.uk/ViewPil.aspx?DocID=8301. 2009-01-21. 2012-02-20. dead.
  2. Web site: Patient Information Leaflets Online: Proctosedyl Suppositories: PL 04425/0208. https://web.archive.org/web/20120220034707/http://xpil.medicines.org.uk/ViewPil.aspx?DocID=8302 . 2009-01-21. 2012-02-20. dead.
  3. Web site: Sanofi Aventis: Hoechst Home Page. https://web.archive.org/web/20091219105719/http://www.sanofi-aventis.de/live/de/de/layout.jsp?scat=AC603939-733B-4C0D-8AAB-0F6E3BF9B2B7. 2009-01-22. 2009-12-19. dead.
  4. Web site: The South African Medical Formulary: C05A Antihaemorrhoidals for topical use. 2009-01-22. https://archive.today/20030330090112/http://web.uct.ac.za/depts/mmi/jmoodie/c05html.html. 2003-03-30. dead.
  5. Web site: NetDoctor: Proctosedyl ointment/suppositories. 2009-01-21.
  6. Maan MS, Mishra R, Thomas S, Hadke NS . Randomized, double-blind trial comparing topical nitroglycerine with xylocaine and Proctosedyl in idiopathic chronic anal fissure . Indian Journal of Gastroenterology . 23 . 3 . 91–3 . 2004 . 15250565.
  7. A general practitioner study to evaluate the efficacy of 'Proctosedyl' ointment in the treatment of acute fissure-in-ano . The British Journal of Clinical Practice . 24 . 7 . 289–91 . July 1970 . 4919315.
  8. Web site: Medsafe: Information for Health Professionals: Proctosedyl . 2009-01-21 . dead . https://web.archive.org/web/20081022155652/http://www.medsafe.govt.nz/profs/Datasheet/p/Proctosedylointsupp.htm . October 22, 2008 .
  9. Damianov L, Katsarova M . [Our experience in using the preparation Proctosedyl from the Roussel firm in pregnant women with hemorrhoids] . Bulgarian . Akusherstvo I Ginekologii͡a . 32 . 3 . 71 . 1993 . 8037333.
  10. Larsen PO . [The Danish fund for basic research--a new cigar-box] . Danish . Ugeskrift for Laeger . 154 . 39 . 2657 . September 1992 . 1413190.
  11. Duncan SH, Leitch EC, Stanley KN, etal . Effects of esculin and esculetin on the survival of Escherichia coli O157 in human faecal slurries, continuous-flow simulations of the rumen and colon and in calves . The British Journal of Nutrition . 91 . 5 . 749–55 . May 2004 . 15137927 . 10.1079/BJN20041101. free .

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