Pro-opiomelanocortin converting enzyme explained

Pro-opiomelanocortin converting enzyme
Ec Number:	3.4.23.17
Cas Number:	80891-34-5

Pro-opiomelanocortin converting enzyme (prohormone converting enzyme, pro-opiomelanocortin-converting enzyme, proopiomelanocortin proteinase, PCE) is an enzyme.^{[1] [2] [3]} This enzyme catalyses the following chemical reaction

Cleavage at paired basic residues in certain prohormones, either between them, or on the carboxyl side

This membrane-bound enzyme is isolated from cattle pituitary secretory vesicle.

Notes and References

1. Loh YP, Parish DC, Tuteja R . Purification and characterization of a paired basic residue-specific pro-opiomelanocortin converting enzyme from bovine pituitary intermediate lobe secretory vesicles . The Journal of Biological Chemistry . 260 . 12 . 7194–205 . June 1985 . 2987247 .
2. Loh YP . Kinetic studies on the processing of human beta-lipotropin by bovine pituitary intermediate lobe pro-opiomelanocortin-converting enzyme . The Journal of Biological Chemistry . 261 . 26 . 11949–55 . September 1986 . 3017955 .
3. Estivariz FE, Birch NP, Loh YP . Generation of Lys-gamma 3-melanotropin from pro-opiomelanocortin 1-77 by a bovine intermediate lobe secretory vesicle membrane-associated aspartic protease and purified pro-opiomelanocortin converting enzyme . The Journal of Biological Chemistry . 264 . 30 . 17796–801 . October 1989 . 2553692 .