Pro-hevein explained
| Pro-hevein |
| Symbol: | HEV1 |
| Cas Number: | 137295-60-4 |
| Uniprot: | P02877 |
Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced[1] and a lectin-like protein from Hevea brasiliensis (rubber tree) where it is involved in the coagulation of latex.[2]
The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain. It has antifungal properties.[3]
Role of hevein in latex allergy
Hevein is the main IgE-binding epitope of the major latex allergen prohevein[4] as are hevein-like protein domains in fruit class I chitinases.[5] Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes.[6] Hevein-like genes can be found in many plants including Arabidopsis thaliana.[7]
Hevein is called Hev b 6 under the WHO allergen nomenclature.[8] [9] There are three entries under this classification, corresponding to the conformational epitopes Hev b 6.01, Hev b 6.03, and Hev b 6.03. They correspond to the full Pro-Havein protein, the matur Hevein (N-terminal), and the C-terminal Barwin domain respectively.[10]
External links
Notes and References
- Broekaert I, Lee HI, Kush A, Chua NH, Raikhel N . Wound-induced accumulation of mRNA containing a hevein sequence in laticifers of rubber tree (Hevea brasiliensis) . Proceedings of the National Academy of Sciences of the United States of America . 87 . 19 . 7633–7 . Oct 1990 . 2217194 . 54802 . 10.1073/pnas.87.19.7633 . 1990PNAS...87.7633B . free .
- Gidrol X, Chrestin H, Tan HL, Kush A . Hevein, a lectin-like protein from Hevea brasiliensis (rubber tree) is involved in the coagulation of latex . The Journal of Biological Chemistry . 269 . 12 . 9278–83 . Mar 1994 . 10.1016/S0021-9258(17)37104-1 . 8132664 . free .
- Van Parijs J, Broekaert WF, Goldstein IJ, Peumans WJ . Hevein: an antifungal protein from rubber-tree (Hevea brasiliensis) latex . Planta . 183 . 2 . 258–64 . Jan 1991 . 24193629 . 10.1007/BF00197797 . 2027.42/47477 . 2490528 . free .
- Alenius H, Kalkkinen N, Reunala T, Turjanmaa K, Palosuo T . The main IgE-binding epitope of a major latex allergen, prohevein, is present in its N-terminal 43-amino acid fragment, hevein . Journal of Immunology . 156 . 4 . 1618–25 . Feb 1996 . 8568268 .
- Dìaz-Perales A, Sánchez-Monge R, Blanco C, Lombardero M, Carillo T, Salcedo G . What is the role of the hevein-like domain of fruit class I chitinases in their allergenic capacity? . Clinical and Experimental Allergy . 32 . 3 . 448–54 . Mar 2002 . 11940077 . 10.1046/j.1365-2222.2002.01306.x . 26003685 . 10553/128107 . free .
- Diaz-Perales A, Collada C, Blanco C, Sánchez-Monge R, Carrillo T, Aragoncillo C, Salcedo G . Class I chitinases with hevein-like domain, but not class II enzymes, are relevant chestnut and avocado allergens . The Journal of Allergy and Clinical Immunology . 102 . 1 . 127–33 . Jul 1998 . 9679856 . 10.1016/s0091-6749(98)70063-6 .
- Potter S, Uknes S, Lawton K, Winter AM, Chandler D, DiMaio J, Novitzky R, Ward E, Ryals J . Regulation of a hevein-like gene in Arabidopsis . Molecular Plant-Microbe Interactions . 6 . 6 . 680–5 . 1993 . 8118053 . 10.1094/mpmi-6-680 .
- Reyes-López CA, Hernández-Santoyo A, Pedraza-Escalona M, Mendoza G, Hernández-Arana A, Rodríguez-Romero A . Insights into a conformational epitope of Hev b 6.02 (hevein) . Biochemical and Biophysical Research Communications . 314 . 1 . 123–30 . Jan 2004 . 14715255 . 10.1016/j.bbrc.2003.12.068 .
- Pedraza-Escalona M, Becerril-Luján B, Agundis C, Domínguez-Ramírez L, Pereyra A, Riaño-Umbarila L, Rodríguez-Romero A . Analysis of B-cell epitopes from the allergen Hev b 6.02 revealed by using blocking antibodies . Molecular Immunology . 46 . 4 . 668–76 . Feb 2009 . 18930549 . 10.1016/j.molimm.2008.08.282 .
- Web site: Hev b 6 Allergen Details . www.allergen.org.
