| Isabella of Armenia | |
| Lady of Tyre | |
| Birth Date: | 1275/1280 |
| Death Date: | Before 9 April 1323 |
| Death Place: | Cilicia |
| House: | Hetoumides |
| Spouse: | Amalric, Lord of Tyre |
| Issue: | Guy of Lusignan John of Lusignan |
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| Issue-Pipe: | more |
| Father: | Leo II, King of Armenia |
| Mother: | Keran of Lampron |
Isabella of Armenia (hy|Զապել; 1275–1280 - murdered in Armenia before 9 April 1323) was the daughter of Leo II of Armenia.
Isabella was the fourth daughter and tenth child of Leo II of Armenia and his wife, Keran; she was also their third daughter to be named Isabella (both previous daughters had died in early childhood). She was the twin sister of Sempad.
She was married at Nicosia in 1292–1293 to Amalric of Cyprus, by whom she had six children:
At some time between 1320 and 1323, Isabella, along with her son Henry, was imprisoned and murdered by Oshin of Corycos. Oshin, who was acting as regent for Leo IV of Armenia, wanted to reduce the number of claimants to the throne of the Cilician Kingdom. It has been rumored that Oshin poisoned Isabella to remove her from the line of inheritance.