Princess Imoukhuede Explained

Princess Imoukhuede
Birth Name:Princess Izevbua Imoukhuede
Workplaces:Washington University in St. Louis
Johns Hopkins University
University of Illinois at Urbana–Champaign
Alma Mater:Massachusetts Institute of Technology
California Institute of Technology
Fields:Systems Biology
Vascular Biology
Cellular and Molecular Bioengineering
Regenerative Medicine
Doctoral Advisor:Henry A. Lester
Awards:National Science Foundation CAREER Award (2017)
Thesis Title:Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1
Thesis Url:https://thesis.library.caltech.edu/958/
Thesis Year:2008

Princess Imoukhuede (born 1980) is an American chemical engineer who is a Professor in Bioengineering at the University of Washington.[1] Before 2022, she was an associate professor at the Washington University in St. Louis. She was awarded the 2018 Illinois Mathematics and Science Academy Distinguished Leadership Award and the 2018 Nano Research Young Innovators Award in Nanobiotechnology. Her first name is 'Princess' and she holds no royal title or position in any capacity.

Early life and education

Imoukhuede grew up in Matteson, Illinois.[2] She was involved with track and field as a child, and competed in shot put from the age of eight. By the time she was in eighth grade she had become interested in science, and her parents gave her a chemistry set to play with at home.[3] Imoukhuede attended the Illinois Mathematics and Science Academy. Imoukhuede was an undergraduate student in biomedical engineering at Massachusetts Institute of Technology (MIT), where she performed undergraduate research under the supervision of Robert S. Langer on the incorporation of adenoviruses in a liposome-based gene therapy system. In her freshman year she was honoured at the Eastern College Athletic Conference, and was the first woman from MIT to qualify for the National Collegiate Athletic Association. Whilst at MIT, Imoukhuede took part in athletics, serving as captain of the varsity track and field team. Imoukhuede was described by Roger Crosley, then MIT Director of Sport, as "the best weight thrower we ever had in track and field". After earning her bachelor's degree, Imoukhuede moved to the California Institute of Technology, where she worked with Henry A. Lester on the structure of the GABA transporter and Förster resonance energy transfer.[4] She was the first African American woman to receive a PhD in bioengineering from Caltech.

Research and career

Imoukhuede was a postdoctoral scholar at Johns Hopkins University, where she specialised in biomedical engineering in the laboratory of Aleksander Popel. She started working on the vascular endothelial growth factor (VEGF) and its receptor (VEGFR) in ischemia and cancer. After completing her postdoctoral research, Imoukhuede joined the University of Illinois at Urbana–Champaign.[5] Currently, Imoukhuede is a professor of bioengineering at the University of Washington as the Hunter and Dorthy Simpson Endowed Chair.[6]

Imoukhuede studies the mechanisms that regulate angiogenic signalling, including tyrosine kinase receptors, VEGF receptors and platelet-derived growth factor receptors. In 2019 Imoukhuede and Sarah K. England partnered to improve the efficacy and safety of oxytocin during labour.[7] Imoukhuede is developing a computational model that could be used to predict the function of oxytocin receptor function. Her current focus is to unravel the complexities governing blood-vessel formation which gives the potential for treatment for several diseases such as breast cancer and some cardiovascular diseases.[8]

Awards and honours

Selected publications

Her publications include:

Notes and References

  1. Web site: 2022-02-18 . Meet Princess Imoukhuede UW Bioengineering . 2023-10-17 . en-US.
  2. Web site: Princess Imoukhuede. 2020-10-21. MIT Spectrum. en-US.
  3. Web site: 2017-08-14. 410: Dr. Princess Imoukhuede: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation. 2020-10-21. People Behind the Science Podcast. en-US.
  4. PhD. Visualizing the membrane confinement, trafficking and structure of the GABA transporter, GAT1. 437168185. California Institute of Technology. 2008. Pasadena, California. en. Princess Izevbua. Imoukhuede.
  5. Web site: Imoukhuede Systems Biology Laboratory. 2020-10-22. en-US.
  6. Web site: Berger . Norbert . 2022-02-18 . Meet Princess Imoukhuede UW Bioengineering . 2024-03-20 . en-US.
  7. Web site: Imoukhuede teams with England on $2.4M NIH grant. 2020-10-21. engineering.wustl.edu. 11 September 2019 . en.
  8. Web site: PBtS . 2017-08-14 . 410: Dr. Princess Imoukhuede: Making Sense of the Signaling Networks that Stimulate Blood Vessel Formation . 2024-03-20 . People Behind the Science Podcast . en-US.
  9. Web site: Princess Imoukhuede – Miniature Brain Machinery . 2024-03-20 . en-US.
  10. Web site: NSF Award Search: Award#1653925 - CAREER: qBio+cBio=sBio; Identifying the role of cross-family signaling in angiogenesis. 2020-10-21. nsf.gov.
  11. Web site: Communications . Grainger Engineering Office of Marketing and . Princess Imoukhuede earns IMSA Distinguished Leadership Award . 2024-03-20 . grainger.illinois.edu . en.
  12. Web site: 2020-07-21 . Princess Imoukhuede . 2024-03-20 . www.aiche.org . en.
  13. Napier. Douglas H.. 1992. Workbook of test cases for vapor cloud source dispersion models, By Steven R. Hanna and David Strimaitis for the Centre for Chemical Process Safety of the American Institute of Chemical Engineers 1989, 122 + xv pages. American Institute of chemical Engineers. New York. 0-8169-0455-3 . The Canadian Journal of Chemical Engineering. 70. 4. 831. 10.1002/cjce.5450700433. 0008-4034.
  14. Web site: 2021-09-20 . Imoukhuede receives 2021 BMES Mid-Career Award . 2024-03-20 . engineering.wustl.edu . en.
  15. Drenan. Ryan M.. Nashmi. Raad. Imoukhuede. Princess. Just. Herwig. McKinney. Sheri. Lester. Henry A.. 2008. Subcellular Trafficking, Pentameric Assembly, and Subunit Stoichiometry of Neuronal Nicotinic Acetylcholine Receptors Containing Fluorescently Labeled α6 and β3 Subunits. Molecular Pharmacology. en. 73. 1. 27–41. 10.1124/mol.107.039180. 0026-895X. 17932221. 14327818.
  16. Imoukhuede. P.I.. Popel. Aleksander S.. 2011. Quantification and cell-to-cell variation of vascular endothelial growth factor receptors. Experimental Cell Research. 317. 7. 955–965. 10.1016/j.yexcr.2010.12.014. 21185287. 3073416. 0014-4827.
  17. Finley. Stacey D. Engel-Stefanini. Marianne O. Imoukhuede. PI. Popel. Aleksander S. 2011. Pharmacokinetics and pharmacodynamics of VEGF-neutralizing antibodies. BMC Systems Biology. 5. 1. 193. 10.1186/1752-0509-5-193. 22104283. 3229549. 1752-0509 . free .
  18. Rubin. Joshua B. Lagas. Joseph S. Broestl. Lauren. Sponagel. Jasmin. Rockwell. Nathan. Rhee. Gina. Rosen. Sarah F. Chen. Si. Klein. Robyn S. Imoukhuede. Princess. Luo. Jingqin. 2020. Sex differences in cancer mechanisms. Biology of Sex Differences. 11. 1. 17 . 10.1186/s13293-020-00291-x. 32295632. 7161126. 2042-6410 . free .

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