| Caroline of Hesse-Homburg | |
| Princess Reuss of Greiz | |
| Birth Date: | 1819 3, df=yes |
| Birth Place: | Bad Homburg vor der Höhe |
| Death Place: | Greiz |
| House: | Hesse |
| Issue: | Christiane, Princess Hugo of Schönburg-Waldenburg Prince Heinrich XXI Heinrich XXII, Prince Reuss of Greiz Prince Heinrich XXIII Marie, Countess Friedrich of Ysenburg and Büdingen in Meerholz |
| Father: | Gustav, Landgrave of Hesse-Homburg |
| Mother: | Princess Louise of Anhalt-Dessau |
Caroline of Hesse-Homburg (1819–1872), was a Princess consort of Reuss of Greiz by marriage to Henry XX, Prince Reuss of Greiz. She was the regent of the Principality of Reuss-Greiz during the minority of her minor son Heinrich XXII, Prince Reuss of Greiz, from 1859 until 1867.
Caroline was eldest child of Gustav, Landgrave of Hesse-Homburg, and his wife, Princess Louise of Anhalt-Dessau.
On 1 October 1839 in Homburg vor der Höhe, she married Henry XX, Prince Reuss of Greiz.
When her spouse died in 1859, she was made regent of the Principality during the minority of her son. When the Austro-Prussian War started in 1866, she chose the side of Austria, which was the reason to why the principality was occupied by Prussia and she was forced to resign.
She had five children: