| Consort: | yes |
| Princess Caroline | |
| Succession: | Princess consort of Anhalt-Zerbst |
| Reign: | 17 November 1753 – 22 May 1759 |
| Spouse: | Frederick Augustus, Prince of Anhalt-Zerbst |
| Full Name: | Caroline Wilhelmina Sophia |
| House: | Hesse-Kassel |
| Father: | Maximilian of Hesse-Kassel |
| Mother: | Friederike Charlotte of Hesse-Darmstadt |
| Birth Date: | 10 May 1732 |
Caroline, Princess of Anhalt-Zerbst (née Princess Caroline Wilhelmina Sophia of Hesse-Kassel; 10 May 1732 – 22 May 1759) was the first wife and consort of Frederick Augustus, Prince of Anhalt-Zerbst.
Princess Caroline Wilhelmina Sophia of Hesse-Kassel was born on 10 May 1732 to Prince Maximilian of Hesse-Kassel and Friederike Charlotte of Hesse-Darmstadt.[1] Her paternal grandparents were Charles I, Landgrave of Hesse-Kassel and Maria Amalia of Courland. Her maternal grandparents were Ernest Louis, Landgrave of Hesse-Darmstadt and Princess Dorothea Charlotte of Brandenburg-Ansbach.
On 17 November 1753 she married Frederick Augustus, Prince of Anhalt-Zerbst in Zerbst, becoming the consort of the Principality of Anhalt-Zerbst. The marriage was childless.
She died on 22 May 1759.