The Primera División Uruguaya 2005 started on 5 March 2005 and ended on 12 July 2005.
The league was a single round-robin tournament and not relegation and promotion from Segunda División Uruguay. But along with Apertura 2005 of 2005–06 season, the whole schedule of 2005 would count in a final table, the bottom three would direct relegated. The winners qualified for 2006 Copa Libertadores.
Defensor Sporting refused to play the tiebreaker match due to Nacional winning their last match by a contested penalty in 7th minute of injury time. Nacional was awarded the championship on 6 July 2005.
| Pos | Name | Team | Goals | |
|---|---|---|---|---|
| 1 | Pablo Granoche | Miramar Misiones | 16 | |
| 2 | Elías Ferreira | Rentistas | 14 | |
| 3 | Sergio Blanco | Wanderers | 12 | |
| 4 | Osvaldo Canobbio | River Plate | 11 | |
| 5 | Martín Ligüera | Nacional | 10 | |
| 6 | Sebastián Taborda | Defensor | 9 | |
| 7 | José Pedro Cardozo | Rocha | 8 | |
| Richard Porta | River Plate | 8 | ||
| Ignacio Risso | Danubio | 8 | ||
| Sebastián Abreu | Nacional | 8 | ||
| Hugo Costela | Defensor | 8 | ||
| Leonardo Medina | Liverpool | 8 |