| Prime -S.E.S. The Best- | |
| Type: | greatest |
| Artist: | S.E.S. |
| Cover: | Prime- S.E.S. the Best.jpg |
| Released: | March 15, 2000 |
| Recorded: | 1999–2000 |
| Genre: | J-pop, dance |
| Length: | 50:11 |
| Language: | Japanese |
| Label: | VAP |
| Prev Title: | Love |
| Prev Year: | 1999 |
| Next Title: | Be Ever Wonderful |
| Next Year: | 2000 |
Prime -S.E.S. The Best- is the first Japanese compilation album by S.E.S., released under VAP on March 15, 2000. It spawned two singles: "T.O.P. (Twinkling of Paradise)" and the double A-side single "Sign of Love" / "Miracle". The album peaked at number 64 on the Oricon Albums Chart and sold 3,750 copies.
The album's first single was "T.O.P. (Twinkling of Paradise)", featuring a rap by Verbal of M-Flo. It was S.E.S.' fourth full Japanese single and sold approximately 5,000 copies. It was released on October 27, 1999.
The double A-side single "Sign of Love" / "Miracle" was the second release spawned from the album and the group's fifth Japanese single. Released on December 8, 1999, it sold approximately 5,000 copies.