Pridefine Explained

Pridefine (AHR-1,118) is a drug which was investigated as an antidepressant in the late 1970s and early 1980s, but was never marketed.^[1] It acts as a balanced reuptake inhibitor of serotonin, dopamine, and norepinephrine, and also has some weak releasing activity.^{[1] [2] [3]}

In clinical trials pridefine was found to be as efficacious as the tricyclic antidepressants amitriptyline and imipramine in the treatment of major depressive disorder but was much more tolerable in comparison and also had an earlier onset of action.^[1] It has been shown to be effective in the treatment of alcoholism as well.^[1]

See also

• Desoxypipradrol
• Diphenylprolinol
• Etifelmine
• Pipradrol
• Piroheptine

Notes and References

1. Vosmer G, DeMet EM, Halaris AE . Action of the antidepressant pridefine (AHR-1118) on biogenic amines in the rat brain . . 29 . 19 . 2557–62 . 1980 . 7426062 . 10.1016/0006-2952(80)90066-0.
2. Halaris AE, Demet EM . Open trial evaluation of a pyrrolidine derivative (AHR-1118) on norepinephrine metabolism . . 4 . 1 . 43–9 . 1980 . 7406986 . 10.1016/0364-7722(80)90060-0.
3. DeMet EM, Vosmer G, Halaris AE . Noncompetitive amine uptake inhibition by the new antidepressant pridefine . . 36 . 3 . 917–23 . 1981 . 7205281 . 10.1111/j.1471-4159.1981.tb01682.x . 1802928 .