| Presidencia Roque Sáenz Peña | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Pushpin Map: | Argentina Chaco Province |
| Pushpin Map Caption: | Location of Presidencia Roque Sáenz Peña in Argentina |
| Coordinates: | -26.7833°N -87°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Comandante Fernández |
| Leader Party: | UCR |
| Leader Title: | Intendant |
| Leader Name: | Bruno Cipolini |
| Unit Pref: | Metric |
| Population Total: | 89,882 |
| Population As Of: | 2010 census |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | H3700 |
| Area Code: | +54 3732 |
| Area Code Type: | Dialing code |
| Blank Name: | Climate |
| Blank Info: | Cfa |
Presidencia Roque Sáenz Peña (normally known as Sáenz Peña) is a city in the . It is the second largest in the province. It is located 170km (110miles) west-northwest of the provincial capital Resistencia, on the main rail and road route across northern Argentina to Salta. The city has a population of 76,377 for the urban area (localidad) and 88,164 for the whole municipality .
Sáenz Peña was founded in 1912 and has developed as a commercial and industrial centre serving the surrounding agricultural region of the Gran Chaco plains.
The city is served by Primer Teniente Jorge Eduardo Casco Airport.