Prephenate dehydratase explained
| prephenate dehydratase |
| Ec Number: | 4.2.1.51 |
| Cas Number: | 9044-88-6 |
| Go Code: | 0004664 |
| Width: | 270 |
The enzyme prephenate dehydratase catalyzes the chemical reaction
prephenate
phenylpyruvate + H
2O + CO
2This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming). This enzyme is also called prephenate hydro-lyase (decarboxylating). This enzyme participates in phenylalanine, tyrosine and tryptophan biosynthesis.
Structural studies
As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code .
References
- CERUTTI P, GUROFF G . Enzymatic Formation of Phenylpyruvic Acid in Pseudomonas Sp. (Atcc 11299A) and ITS Regulation . 1965 . J. Biol. Chem. . 240 . 3034 - 8 . 14342329 .
- COTTON RG, GIBSON F . The biosynthesis of phenylalanine and tyrosine; enzymes converting chorismic acid into prephenic acid and their relationships to prephenate dehydratase and prephenate dehydrogenase . 1965 . Biochim. Biophys. Acta . 100 . 76 - 88 . 14323651 . 10.1016/0304-4165(65)90429-0.
- Schmidt JC . Zalkin H . 1969 . Chorismate mutase-prephenate dehydratase. Partial purification and properties of the enzyme from Salmonella typhimurium . Biochemistry . 8 . 174 - 181 . 10.1021/bi00829a025 . 4887851 . 1.
