| Prentiss High School | |
| Streetaddress: | 2429 Mississippi Avenue |
| City: | Prentiss |
| State: | Mississippi |
| Zipcode: | 39474 |
| Country: | United States |
| Principal: | Pete Howell |
| Faculty: | 47 |
| Enrollment: | 619 (2008-2009) |
| Grades: | 7-12 |
| Conference: | Mississippi Southeastern Conference |
| Fightsong: | Go Mighty Bulldogs |
| Rival: | Bassfield Yellowjackets |
| Mascot: | Bulldog |
| Sports: | Basketball, softball, track, baseball, football, volleyball, band, golf |
| Team Name: | Bulldogs |
| Nickname: | PHS |
| School Colours: | Black, red and white |
Prentiss High School was a high school located in Prentiss, Mississippi, United States. It was a part of the Jefferson Davis County School District. It ceased operations at the end of the 2016–17 school year.