Prenderol Explained

Prenderol (Diethylpropanediol) is a simple alkyl diol which has sedative, anticonvulsant and muscle relaxant effects. It is closely related in structure to meprobamate and numerous other alkyl alcohols and diols with generally comparable activity.^{[1] [2] [3] [4] [5] [6]}

Synthesis

Treatment of the aldehyde 2-ethylbutyraldehyde with formaldehyde and potassium hydroxide gives a crossed Cannizzaro reaction yieldingprenderol.^[7]

See also

• 1,3-Propanediol
• 2-Methyl-2-propyl-1,3-propanediol
• Phenaglycodol

Notes and References

1. Berger FM . Anticonvulsant action of 2-substituted-1,3-propanediols . Proceedings of the Society for Experimental Biology and Medicine . New York, N.Y. . 71 . 2 . 270–271 . June 1949 . 18134033 . 10.3181/00379727-71-17159 . 32255832 .
2. Funderburk WH, Unna KR . Site of action of 2, 2-diethyl-1,3-propanediol (prenderol) on the central nervous system . The Journal of Pharmacology and Experimental Therapeutics . 107 . 3 . 344–55 . March 1953 . 13035673 .
3. Mailer AB . Effects of mephenesin and prenderol on intellectual functions of mental patients . Journal of Clinical Psychology . 10 . 3 . 283–5 . July 1954 . 13163224 . 10.1002/1097-4679(195407)10:3<283::aid-jclp2270100322>3.0.co;2-a .
4. Blum B . Head shaking and nystagmus produced by 2,2-diethyl, 1,3-propanediol (prenderol) in the rat . Archives Internationales de Pharmacodynamie et de Therapie . 137 . 128–36 . May 1962 . 13870189 .
5. Reyes Q., Aaurelio; Mascetti V., G.; Martinez J., Rolando. Synthesis of polyhydroxylated alcohols. Revista Latinoamericana de Quimica 1984; 15 (1): 29-30. ISSN: 0370-5943.
6. Wang G, Lu Q . A nitrate ester of sedative alkyl alcohol improves muscle function and structure in a murine model of Duchenne muscular dystrophy . Molecular Pharmaceutics . 10 . 10 . 3862–70 . October 2013 . 23924275 . 10.1021/mp400310r .
7. 10.1021/ja01185a602 . New Compounds. New Compounds as Insect Repellents . 1948 . McKusick . B. . Journal of the American Chemical Society . 70 . 5 . 1982–1983 .