| Iupac Name: | [(3''S'',8''S'',9''S'',10''R'',13''S'',14''S'',17''S'')-17-Acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1''H''-cyclopenta[''a'']phenanthren-3-yl] acetate |
| Width: | 250px |
| Tradename: | Antofin, Previsone, Pregno-Pan |
| Routes Of Administration: | Topical |
| Cas Number: | 1778-02-5 |
| Pubchem: | 2723722 |
| Drugbank: | DB14626 |
| Chemspiderid: | 2005918 |
| Unii: | 0G0WWV404B |
| Kegg: | C14658 |
| Chebi: | 34930 |
| Chembl: | 1892286 |
| Synonyms: | Pregn-5-en-3β-ol-20-one 3β-acetate, Antofin, Artivis, Enescorb, Previsone, Sharmone, Pregnenolone-3-acetate, 1778-02-5, 3α-Acetoxy-5-pregnen-20-one, ZINC6304690, NSC 64827, Acetic acid 20-oxopregn-5-en-3alpha-yl ester[1] |
| C: | 23 |
| H: | 34 |
| O: | 3 |
| Smiles: | CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC(=O)C)C)C |
| Stdinchi: | 1S/C23H34O3/c1-14(24)19-7-8-20-18-6-5-16-13-17(26-15(2)25)9-11-22(16,3)21(18)10-12-23(19,20)4/h5,17-21H,6-13H2,1-4H3/t17-,18-,19+,20-,21-,22-,23+/m0/s1 |
| Stdinchikey: | CRRKVZVYZQXICQ-RJJCNJEVSA-N |
Pregnenolone acetate (brand names Antofin, Previsone, Pregno-Pan), also known as pregn-5-en-3β-ol-20-one 3β-acetate, is a synthetic pregnane steroid and an ester of pregnenolone which is described as a glucocorticoid and as a skin-conditioning and skin anti-aging agent.[2] [3] It has been reported to reduce wrinkles in elderly women when applied in the form of a 0.5% topical cream, effects which were suggested to be due to improved hydration of the skin. Pregnenolone acetate has been marketed in France in a topical cream containing 1% pregnenolone acetate and 10% "sex hormone" for the treatment of premature skin aging but was withdrawn from the market in 1992. Although the medication has been described by some sources as a glucocorticoid, other authors have stated that systemic pregnenolone acetate has no undesirable metabolic or toxic effects even at high doses.[4]