Prasterone sulfate explained

Prasterone sulfate (brand names Astenile, Mylis, Teloin, others), also known as dehydroepiandrosterone sulfate (DHEA-S), is a naturally occurring androstane steroid which is marketed and used in Japan and other countries as a labor inducer in the treatment of insufficient cervical ripening and dilation during childbirth.[1] [2] [3] [4] [5] [6] [7] [8] It is the C3β sulfate ester of prasterone (dehydroepiandrosterone; DHEA), and is known to act as a prohormone of DHEA and by extension of androgens and estrogens,[9] although it also has its own activity as a neurosteroid.[10] Prasterone sulfate is used medically as the sodium salt via injection and is referred to by the name sodium prasterone sulfate .[11]

Prasterone sulfate is available in Japan, Italy, Portugal, Argentina, and China.[12] Brand names include Astenile, Dastonil, Di Luo An, Dinistenile, Levospa, Mylis, Sinsurrene, and Teloin.

See also

Notes and References

  1. Sakaguchi M, Sakai T, Adachi Y, Kawashima T, Awata N . The biological fate of sodium prasterone sulfate after vaginal administration. I. Absorption and excretion in rats . J. Pharmacobio-Dyn. . 15 . 2 . 67–73 . 1992 . 1403604 . 10.1248/bpb1978.15.67. free .
  2. Book: Negwer M, Scharnow HG . Organic-chemical drugs and their synonyms: (an international survey). 2001. Wiley-VCH. 978-3-527-30247-5. 1831. 3β-Hydroxyandrost-5-en-17-one hydrogen sulfate = (3β)-3-(Sulfooxy)androst-5-en-17-one. R: Sodium salt (1099-87-2). S: Astenile, Dehydroepiandrosterone sulfate sodium, DHA-S, DHEAS, KYH 3102, Mylis, PB 005, Prasterone sodium sulfate, Teloin.
  3. Book: Elks J . The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. 14 November 2014. Springer. 978-1-4757-2085-3. 641–.
  4. Book: Blunt JW, Munro MH . 3-hydroxyandrost-5-en-17-one . Dictionary of Marine Natural Products with CD-ROM. https://books.google.com/books?id=w1bLBQAAQBAJ&pg=PA1075. 19 September 2007. CRC Press. 978-0-8493-8217-8. 1075–.
  5. Book: Kleemann A, Engel J, Kutscher B, Reichert D. Pharmaceutical Substances, 5th Edition, 2009: Syntheses, Patents and Applications of the most relevant APIs. 14 May 2014. Thieme. 978-3-13-179525-0. 2441–2442.
  6. Jianqiu Y . 1992 . Clinical Application of Prasterone Sodium Sulfate . Chinese Journal of New Drugs . 5 . 015 .
  7. Sakai T, Sakaguchi M, Adachi Y, Kawashima T, Awata N . 1992 . The Biological Fate of Sodium Prasterone Sulfate after Vaginal Administration II: Distribution after Single and Multiple Administration to Pregnant Rats. . 薬物動態 (Pharmacokinetics) . 7 . 1 . 87–101 .
  8. Web site: Prasterone (Dehydroepiandrosterone, DHEA) vaginal Uses, Side Effects & Warnings . drugs.com .
  9. Mueller JW, Gilligan LC, Idkowiak J, Arlt W, Foster PA . The Regulation of Steroid Action by Sulfation and Desulfation . Endocr. Rev. . 36 . 5 . 526–63 . 2015 . 26213785 . 4591525 . 10.1210/er.2015-1036 .
  10. Gibbs TT, Russek SJ, Farb DH . Sulfated steroids as endogenous neuromodulators . Pharmacol. Biochem. Behav. . 84 . 4 . 555–67 . 2006 . 17023038 . 10.1016/j.pbb.2006.07.031 . 33659983 .
  11. Web site: 1099-87-2 - GFJWACFSUSFUOG-ZJTJBYBXSA-M - Sodium prasterone sulfate [JAN] - Similar structures search, synonyms, formulas, resource links, and other chemical information. ChemIDplus . U.S. National Library of Medicine .
  12. Web site: Micromedex . Merative US L.P. .

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