| Official Name: | Prairie Creek, Indiana |
| Settlement Type: | Unincorporated community |
| Mapsize: | 150px |
| Pushpin Map: | USA Indiana Vigo County |
| Pushpin Label: | Prairie Creek |
| Pushpin Map Caption: | Prairie Creek's location in Vigo County, Indiana |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Indiana |
| Subdivision Type2: | County |
| Subdivision Name2: | Vigo |
| Subdivision Type3: | Township |
| Subdivision Name3: | Prairie Creek |
| Timezone: | Eastern (EST) |
| Utc Offset: | -5 |
| Timezone Dst: | EDT |
| Utc Offset Dst: | -4 |
| Coordinates: | 39.275°N -87.4972°W |
| Elevation Footnotes: | [1] |
| Elevation M: | 161 |
| Elevation Ft: | 528 |
| Postal Code Type: | ZIP code |
| Postal Code: | 47869 |
| Area Code: | 812, 930 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 447631 |
Prairie Creek (also Middletown) is an unincorporated community in southeastern Prairie Creek Township, Vigo County, in the U.S. state of Indiana.[2] Its elevation is 528 feet (161 m), and it is located at 39.275°N -87.4972°W (39.2750390, -87.4972443). Because the community has had multiple names, the Board on Geographic Names officially decided in favor of "Prairie Creek" in 1959.[3] Although Prairie Creek is unincorporated, it has a post office, with the ZIP code of 47869.[4]
The community is part of the Terre Haute Metropolitan Statistical Area.
The town of Middletown was laid out August 24, 1831, by James D. Piety on the old Vincennes Road. Early businesses included Daniel Ryerson's hotel and drug store, Jonas P. Lykins's store, Z. J. Hunt's hotel, and Hiram Hight's steam mill in 1847. Jacob Ernest built the first brick house, in 1849.[5]
The post office at Prairie Creek has been in operation since 1822.[6]
Prairie Creek lies at the intersection of State Roads 63 and 246 southwest of the city of Terre Haute, the county seat of Vigo County.[7]