Poxvirus AX element late mRNA cis-regulatory element explained

Poxvirus AX element late mRNA cis-regulatory element
Symbol:Pox_AX_element
Rfam:RF00384
Rna Type:Cis-reg
Tax Domain:Viruses

The Poxvirus AX element late mRNA family represents a cis-regulatory element present at the 3' end of poxvirus late ATI mRNA and is known as the AX element. The AX element is involved in directing the efficient production and orientation-dependent formation of late RNAs.[1] It is likely that this element directs the endonucleolytic cleavage of the transcript. It has been shown that the F17R late mRNA transcript which is also cleaved is also likely to share a common factor in their mechanism despite a lack of any obvious similarity in its cis-regulatory RNA element.[2]

See also

Notes and References

  1. Howard . ST . Ray CA . Patel DD . Antczak JB . Pickup DJ . 1999 . A 43-nucleotide RNA cis-acting element governs the site-specific formation of the 3' end of a poxvirus late mRNA . Virology . 255 . 190–204 . 10049834 . 10.1006/viro.1998.9547 . 1. free .
  2. D'Costa SM, Antczak JB, Pickup DJ, Condit RC . Post-transcription cleavage generates the 3' end of F17R transcripts in vaccinia virus . Virology . 319 . 1 . 1–11 . February 2004 . 14967483 . 10.1016/j.virol.2003.09.041 . free .