Powellsville is an unincorporated community in Scioto County, in the U.S. state of Ohio.
Powellsville was platted about 1848 by William Powell and others, and named for its founder.[1] A post office was established in Powellsville in 1860, and remained in operation until 1906.[2] In 1990, a 4310 gram chondrite (H5) meteorite was found ~40 cm underground by a man digging out a tree stump in his yard.[3]