Potassium canrenoate explained

Potassium canrenoate (INN, JAN) or canrenoate potassium (USAN) (brand names Venactone, Soldactone), also known as aldadiene kalium,^[1] the potassium salt of canrenoic acid, is an aldosterone antagonist of the spirolactone group.^[2] Like spironolactone, it is a prodrug, and is metabolized to active canrenone in the body.^{[3] [4]}

Potassium canrenoate is notable in that it is the only clinically used antimineralocorticoid which is available for parenteral administration (specifically intravenous)^[5] as opposed to oral administration.^[6]

In the UK, it is unlicensed and only used for short term diuresis in oedema or heart failure in neonates or children under specialist initiation and monitoring.

See also

• Canrenoic acid
• Canrenone

Notes and References

1. Book: Selye H . Hormones and Resistance: Part 1 and. 17 April 2013. Springer Science & Business Media. 978-3-642-65192-2. 186–.
2. Book: Hill RA, Makin HL, Kirk DN, Murphy GM . Dictionary of Steroids. 23 May 1991. CRC Press. 978-0-412-27060-4. 656–.
3. Book: Burger A, Wolff ME . Burger's Medicinal Chemistry and Drug Discovery: Therapeutic agents. 1996. Wiley. 978-0-471-57557-3.
4. Book: Waldmann C, Soni N, Rhodes A . Diurectics and the Critical Ill . Oxford Desk Reference: Critical Care. https://books.google.com/books?id=eLqMpXfAlEcC&pg=PA187. 27 November 2008. OUP Oxford. 978-0-19-922958-1. 187–.
5. Book: Santambrogio R, Barabino M, Opocher E . Non-resection: Radiofrequency Ablation, Cryo, Microwave . Bonjer HJ . Surgical Principles of Minimally Invasive Procedures: Manual of the European Association of Endoscopic Surgery (EAES). https://books.google.com/books?id=tAImDwAAQBAJ&pg=PA136. 21 June 2017. Springer. 978-3-319-43196-3. 136–.
6. Kolkhof P, Bärfacker L . 30 YEARS OF THE MINERALOCORTICOID RECEPTOR: Mineralocorticoid receptor antagonists: 60 years of research and development . The Journal of Endocrinology . 234 . 1 . T125–T140 . July 2017 . 28634268 . 5488394 . 10.1530/JOE-16-0600 .