| Competition: | Primeira Liga |
| Season: | 1980–81 |
| Winners: | Benfica 24th title |
| Relegated: | Varzim Marítimo Académica |
| Continentalcup1: | European Cup |
| Continentalcup1 Qualifiers: | Benfica |
| Continentalcup2: | Cup Winners' Cup |
| Continentalcup2 Qualifiers: | Porto |
| Continentalcup3: | UEFA Cup |
| Continentalcup3 Qualifiers: | Sporting CP Boavista |
| Matches: | 240 |
| Total Goals: | 560 |
| League Topscorer: | Nené (20 goals) |
| Prevseason: | 1979–80 |
| Nextseason: | 1981–82 |
The 1980–81 Primeira Divisão was the 47th season of top-tier football in Portugal.
It was contested by 16 teams, and S.L. Benfica won the championship.
| Rank | Player | Club | Goals[1] |
|---|---|---|---|
| 1 | Nené | Benfica | 20 |
| 2 | Jacques | Braga | 17 |
| 3 |  Mickey Walsh | Porto | 14 |
| Jorge Silva | Amora | ||
| Rui Jordão | Sporting | ||
| João Alves | Benfica | ||
| 7 | Júlio Carlos | Boavista | 13 |
| 8 | Folha | Boavista | 12 |
| 9 |  César | Benfica | 10 |
| António Oliveira | Penafiel | ||
| Manuel Fernandes | Sporting |