| Portrait of Maffeo Barberini | |
| Other Language 1: | Italian |
| Other Title 1: | Ritratto di Maffeo Barberini |
| Artist: | Caravaggio |
| Year: | c. 1598 |
| Medium: | Oil on canvas |
| Height Metric: | 124 |
| Width Metric: | 90 |
| Metric Unit: | cm |
| Imperial Unit: | in |
| Museum: | Private collection |
Portrait of Maffeo Barberini (c. 1598) is a painting by the Italian Baroque master Michelangelo Merisi da Caravaggio. It is in a private collection in Los Angeles.
Barberini, 30 years old and from the eminent Florentine Barberini family, was a rapidly rising Church prelate, a friend of Caravaggio's patron Cardinal Francesco Maria Del Monte, and himself a poet and patron of the arts. Barberini's support would continue into later years – in 1603 he commissioned a Sacrifice of Isaac from Caravaggio. In 1623 he became Pope as Urban VIII.