| Porto–Lisboa | |
| Date: | June 10 |
| Region: | Portugal |
| English: | OPorto–Lisbon |
| Localnames: | Porto–Lisboa |
| Discipline: | Road race |
| Competition: | Classic race |
| Type: | Single-day |
| Organiser: | UVP-FPC |
| Number: | 74 |
| Last: | 2004 |
| Mostwins: | 3 times: |
Porto–Lisbon (Portuguese: Porto–Lisboa) was an annual road cycling race held in Portugal on 10 June in celebration of Portugal Day. Covering a distance of approximately 330-340 kilometres, the race was the longest on the professional calendar after the disappearance of Bordeaux–Paris in 1988. It started in Porto, Portugal's second-largest city, and finished in the Portuguese capital Lisbon around eight or nine hours later.
Although it was the most important classic in Portugal, in its later days it was usually only contested by Portuguese cycling teams. In 2002 Porto–Lisbon was held as a team-race divided in three sectors between Porto and Lisboa. In 2004 the last edition of the race was held. Since its cancellation, Milan–San Remo is the longest one-day race of the year, at approximately 298 km.