| Port Region | |
| Native Name: | Reġjun tal-Port |
| Native Name Lang: | mt |
| Settlement Type: | Region of Malta |
| Mapsize: | 155px |
| Coordinates: | 35.8659°N 14.5138°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Malta |
| Subdivision Type1: | Island |
| Subdivision Name1: | Malta |
| Established Title: | Act No. XIV of 2019 |
| Established Date: | 26 April 2019 |
| Seat: | Tarxien |
| Government Footnotes: | Regional Council |
| Leader Title: | Regional President |
| Leader Name: | Paul Farrugia |
| Unit Pref: | Metric |
| Area Total Km2: | 15.75 |
| Population As Of: | 2020 |
| Population Total: | 69880 |
| Population Density Km2: | auto |
| Timezone1: | UTC+1 |
| Area Code Type: | Dialing code |
| Area Code: | 356 |
| Website: | Official Website |
| Blank Name Sec1: | Local councils |
| Blank Info Sec1: | 11 |
The Port Region (Maltese: Reġjun tal-Port) is one of the six regions of Malta. The region is located in the southeastern part of the main island of Malta. The region borders the Eastern and Southern Regions.
It was created by the Act No. XIV of 2019 out of part of the South Eastern Region, and became effective in 2022[1]
Port Region includes most of the Southern Harbour district.
Port Region includes 11 local councils: