| Port-Sainte-Marie | |
| Commune Status: | Commune |
| Image Coat Of Arms: | Blason ville fr Port-Sainte-Marie (Lot-et-Garonne).svg |
| Arrondissement: | Agen |
| Canton: | Le Confluent |
| Insee: | 47210 |
| Postal Code: | 47130 |
| Mayor: | Jacques Larroy[1] |
| Term: | 2020 - 2026 |
| Intercommunality: | Confluent et Coteaux de Prayssas |
| Coordinates: | 44.2517°N 0.3981°W |
| Elevation M: | 41 |
| Elevation Min M: | 27 |
| Elevation Max M: | 216 |
| Area Km2: | 18.94 |
Port-Sainte-Marie (pronounced as /fr/; oc|Lo Pòrt) is a commune in the Lot-et-Garonne department in south-western France. Port-Sainte-Marie station has rail connections to Agen, Langon and Bordeaux.