Popeye protein conserved region explained

Symbol:	Popeye
Popeye protein conserved region
Pfam:	PF04831
Interpro:	IPR006916

Popeye protein conserved region is common to a family of evolutionarily related proteins, the Popeye domain containing (POPDC) family of proteins, which is found in many animal phyla (vertebrates, lower chordates, arthropodes, mollusca and some protostomia).^[1]

In vertebrates it is preferentially expressed in developing and adult striated muscle (heart and skeletal muscle). It is represented by a conserved region, the Popeye domain, which functions as a cAMP-binding domain. All POPDC proteins also have three potential transmembrane domains.^[2] The strong conservation of POPDC genes during evolution and their preferential expression in heart and skeletal muscle suggest that these proteins may have an important function in these tissues in vertebrates.

Notes and References

1. Schindler RF, Scotton C, French V, Ferlini A, Brand T . The Popeye Domain Containing Genes and their Function in Striated Muscle . Journal of Cardiovascular Development and Disease . 3 . 2 . 22 . June 2016 . 27347491 . 10.3390/jcdd3020022 . 4918794 . free .
2. Andrée B, Hillemann T, Kessler-Icekson G, Schmitt-John T, Jockusch H, Arnold HH, Brand T . Isolation and characterization of the novel popeye gene family expressed in skeletal muscle and heart . Developmental Biology . 223 . 2 . 371–82 . July 2000 . 10882522 . 10.1006/dbio.2000.9751 . free .