| Type: | Pope |
| Honorific-Prefix: | Pope |
| Matthew II of Alexandria | |
| Pope of Alexandria and Patriarch of the See of St. Mark | |
| Enthroned: | 1452 |
| Ended: | 23 September 1465 |
| Predecessor: | John XI |
| Successor: | Gabriel VI |
| Birth Place: | Egypt |
| Death Date: | 23 September 1465 |
| Death Place: | Egypt |
| Buried: | Khandaq Monastery of Saint Ruwais |
| Nationality: | Egyptian |
| Religion: | Coptic Orthodox Christian |
| Residence: | Church of the Virgin Mary (Haret Zuweila) |
Pope Matthew (Matthias) the Second was the 90th Pope of Alexandria and Patriarch of the See of St. Mark. He became a monk in El-Muharraq Monastery and later was Coptic Pope for thirteen years.[1] He is commemorated in the Calendar of Saints of the Coptic Church on the 13th day of Thout.